Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases

The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease mo...

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Autores principales:	Paul S. Fishman, Johnathan M. Fischell
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	FUS blood-brain barrier Alzheimer's disease Parkinson's disease focused ultrasound (MRgFUS) Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0e5158b818394293a24b3466b87aae1d
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spelling	oai:doaj.org-article:0e5158b818394293a24b3466b87aae1d2021-11-04T05:46:52ZFocused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases1664-229510.3389/fneur.2021.749047https://doaj.org/article/0e5158b818394293a24b3466b87aae1d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.749047/fullhttps://doaj.org/toc/1664-2295The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease modifying therapies for these progressive conditions, strategies to deliver these large agents remain limited. High intensity MRI guided focused ultrasound has already been FDA approved to lesion brain targets to treat movement disorders, while lower intensity pulsed ultrasound coupled with microbubbles commonly used as contrast agents can create transient safe opening of the BBB. Pre-clinical studies have successfully delivered growth factors, antibodies, genes, viral vectors, and nanoparticles in rodent models of AD and PD. Recent small clinical trials support the safety and feasibility of this strategy in these vulnerable patients. Further study is needed to establish safety as MRI guided BBB opening is used to enhance the delivery of newly developed molecular therapies.Paul S. FishmanJohnathan M. FischellFrontiers Media S.A.articleFUSblood-brain barrierAlzheimer's diseaseParkinson's diseasefocused ultrasound (MRgFUS)Neurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FUS blood-brain barrier Alzheimer's disease Parkinson's disease focused ultrasound (MRgFUS) Neurology. Diseases of the nervous system RC346-429
spellingShingle	FUS blood-brain barrier Alzheimer's disease Parkinson's disease focused ultrasound (MRgFUS) Neurology. Diseases of the nervous system RC346-429 Paul S. Fishman Johnathan M. Fischell Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
description	The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease modifying therapies for these progressive conditions, strategies to deliver these large agents remain limited. High intensity MRI guided focused ultrasound has already been FDA approved to lesion brain targets to treat movement disorders, while lower intensity pulsed ultrasound coupled with microbubbles commonly used as contrast agents can create transient safe opening of the BBB. Pre-clinical studies have successfully delivered growth factors, antibodies, genes, viral vectors, and nanoparticles in rodent models of AD and PD. Recent small clinical trials support the safety and feasibility of this strategy in these vulnerable patients. Further study is needed to establish safety as MRI guided BBB opening is used to enhance the delivery of newly developed molecular therapies.
format	article
author	Paul S. Fishman Johnathan M. Fischell
author_facet	Paul S. Fishman Johnathan M. Fischell
author_sort	Paul S. Fishman
title	Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
title_short	Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
title_full	Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
title_fullStr	Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
title_full_unstemmed	Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases
title_sort	focused ultrasound mediated opening of the blood-brain barrier for neurodegenerative diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0e5158b818394293a24b3466b87aae1d
work_keys_str_mv	AT paulsfishman focusedultrasoundmediatedopeningofthebloodbrainbarrierforneurodegenerativediseases AT johnathanmfischell focusedultrasoundmediatedopeningofthebloodbrainbarrierforneurodegenerativediseases
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Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases

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