Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study

Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility. Given the impact of immune responses linked to GW...

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Autores principales:	Janet K. Coller, Jonathan Tuke, Taylor J. Wain, Emily Quinn, Lea Steele, Maria Abreu, Kristina Aenlle, Nancy Klimas, Kimberly Sullivan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Gulf War illness immune genetics toll-like receptor 4 predictive genetic model objective biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0e53061fb24c48729477aea90d16f70f
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spelling	oai:doaj.org-article:0e53061fb24c48729477aea90d16f70f2021-11-25T16:56:43ZAssociations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study10.3390/brainsci111114102076-3425https://doaj.org/article/0e53061fb24c48729477aea90d16f70f2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1410https://doaj.org/toc/2076-3425Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility. Given the impact of immune responses linked to GWI symptomology, genetic variability that causes persistent inflammatory/immune alterations may be key. This Boston University-based Gulf War Illness Consortium (GWIC) study investigated the impact of single nucleotide polymorphisms (SNPs) in variants of immune and pain genetic markers <i>IL1B</i>, <i>IL2</i>, <i>IL6</i>, <i>IL6R</i>, <i>IL10</i>, <i>TNF</i>, <i>TGF</i>, <i>TLR2</i>, <i>TLR4</i>, <i>MD2</i>, <i>MYD88</i>, <i>BDNF</i>, <i>CRP</i>, <i>ICE, COMT</i> and <i>OPRM1</i> on GWI occurrence in a Caucasian subset of Gulf War (GW) veterans with (cases, <i>n</i> = 170) and without (controls, <i>n</i> = 34) GWI. Logistic regression modeling created a prediction model of GWI risk that associated genetic variability in <i>TGF</i> (rs1800469, <i>p</i> = 0.009), <i>IL6R</i> (rs8192284, <i>p</i> = 0.004) and <i>TLR4</i> (rs4986791, <i>p</i> = 0.013) with GWI occurrence. This prediction model was specific and sensitive, with a receiver operator characteristic area under the curve of 71.4%. This is the first report of immune genetic variability being predictive of GWI and warrants validation in larger independent cohorts. Future reports will present interactions of these genetic risk factors with other characteristics of GW service.Janet K. CollerJonathan TukeTaylor J. WainEmily QuinnLea SteeleMaria AbreuKristina AenlleNancy KlimasKimberly SullivanMDPI AGarticleGulf War illnessimmune geneticstoll-like receptor 4predictive genetic modelobjective biomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1410, p 1410 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gulf War illness immune genetics toll-like receptor 4 predictive genetic model objective biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Gulf War illness immune genetics toll-like receptor 4 predictive genetic model objective biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Janet K. Coller Jonathan Tuke Taylor J. Wain Emily Quinn Lea Steele Maria Abreu Kristina Aenlle Nancy Klimas Kimberly Sullivan Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
description	Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility. Given the impact of immune responses linked to GWI symptomology, genetic variability that causes persistent inflammatory/immune alterations may be key. This Boston University-based Gulf War Illness Consortium (GWIC) study investigated the impact of single nucleotide polymorphisms (SNPs) in variants of immune and pain genetic markers <i>IL1B</i>, <i>IL2</i>, <i>IL6</i>, <i>IL6R</i>, <i>IL10</i>, <i>TNF</i>, <i>TGF</i>, <i>TLR2</i>, <i>TLR4</i>, <i>MD2</i>, <i>MYD88</i>, <i>BDNF</i>, <i>CRP</i>, <i>ICE, COMT</i> and <i>OPRM1</i> on GWI occurrence in a Caucasian subset of Gulf War (GW) veterans with (cases, <i>n</i> = 170) and without (controls, <i>n</i> = 34) GWI. Logistic regression modeling created a prediction model of GWI risk that associated genetic variability in <i>TGF</i> (rs1800469, <i>p</i> = 0.009), <i>IL6R</i> (rs8192284, <i>p</i> = 0.004) and <i>TLR4</i> (rs4986791, <i>p</i> = 0.013) with GWI occurrence. This prediction model was specific and sensitive, with a receiver operator characteristic area under the curve of 71.4%. This is the first report of immune genetic variability being predictive of GWI and warrants validation in larger independent cohorts. Future reports will present interactions of these genetic risk factors with other characteristics of GW service.
format	article
author	Janet K. Coller Jonathan Tuke Taylor J. Wain Emily Quinn Lea Steele Maria Abreu Kristina Aenlle Nancy Klimas Kimberly Sullivan
author_facet	Janet K. Coller Jonathan Tuke Taylor J. Wain Emily Quinn Lea Steele Maria Abreu Kristina Aenlle Nancy Klimas Kimberly Sullivan
author_sort	Janet K. Coller
title	Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
title_short	Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
title_full	Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
title_fullStr	Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
title_full_unstemmed	Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study
title_sort	associations of immune genetic variability with gulf war illness in 1990–1991 gulf war veterans from the gulf war illness consortium (gwic) multisite case-control study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0e53061fb24c48729477aea90d16f70f
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Associations of Immune Genetic Variability with Gulf War Illness in 1990–1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study

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