Hippocampal sharp-wave ripples in awake mice are entrained by respiration

Abstract Several recent studies have shown that respiration modulates oscillatory neuronal activity in the neocortex and hippocampus on a cycle-by-cycle basis. It was suggested that this respiratory influence on neuronal activity affects cognitive functions, including memory. Sharp-wave ripples (SWR...

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Autores principales:	Yu Liu, Samuel S. McAfee, Detlef H. Heck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e5661aaeff947f8a90f1ea8f84edcd5
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spelling	oai:doaj.org-article:0e5661aaeff947f8a90f1ea8f84edcd52021-12-02T12:32:54ZHippocampal sharp-wave ripples in awake mice are entrained by respiration10.1038/s41598-017-09511-82045-2322https://doaj.org/article/0e5661aaeff947f8a90f1ea8f84edcd52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09511-8https://doaj.org/toc/2045-2322Abstract Several recent studies have shown that respiration modulates oscillatory neuronal activity in the neocortex and hippocampus on a cycle-by-cycle basis. It was suggested that this respiratory influence on neuronal activity affects cognitive functions, including memory. Sharp-wave ripples (SWRs) are high-frequency local field potential activity patterns characteristic for the hippocampus and implicated in memory consolidation and recall. Here we show that the timing of SWR events is modulated by the respiratory cycle, with a significantly increased probability of SWRs during the early expiration phase. This influence of respiration on SWR occurrence was eliminated when olfactory bulb activity was inhibited. Our findings represent a possible neuronal mechanism for a direct influence of the respiratory cycle on memory function.Yu LiuSamuel S. McAfeeDetlef H. HeckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Liu Samuel S. McAfee Detlef H. Heck Hippocampal sharp-wave ripples in awake mice are entrained by respiration
description	Abstract Several recent studies have shown that respiration modulates oscillatory neuronal activity in the neocortex and hippocampus on a cycle-by-cycle basis. It was suggested that this respiratory influence on neuronal activity affects cognitive functions, including memory. Sharp-wave ripples (SWRs) are high-frequency local field potential activity patterns characteristic for the hippocampus and implicated in memory consolidation and recall. Here we show that the timing of SWR events is modulated by the respiratory cycle, with a significantly increased probability of SWRs during the early expiration phase. This influence of respiration on SWR occurrence was eliminated when olfactory bulb activity was inhibited. Our findings represent a possible neuronal mechanism for a direct influence of the respiratory cycle on memory function.
format	article
author	Yu Liu Samuel S. McAfee Detlef H. Heck
author_facet	Yu Liu Samuel S. McAfee Detlef H. Heck
author_sort	Yu Liu
title	Hippocampal sharp-wave ripples in awake mice are entrained by respiration
title_short	Hippocampal sharp-wave ripples in awake mice are entrained by respiration
title_full	Hippocampal sharp-wave ripples in awake mice are entrained by respiration
title_fullStr	Hippocampal sharp-wave ripples in awake mice are entrained by respiration
title_full_unstemmed	Hippocampal sharp-wave ripples in awake mice are entrained by respiration
title_sort	hippocampal sharp-wave ripples in awake mice are entrained by respiration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e5661aaeff947f8a90f1ea8f84edcd5
work_keys_str_mv	AT yuliu hippocampalsharpwaveripplesinawakemiceareentrainedbyrespiration AT samuelsmcafee hippocampalsharpwaveripplesinawakemiceareentrainedbyrespiration AT detlefhheck hippocampalsharpwaveripplesinawakemiceareentrainedbyrespiration
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Hippocampal sharp-wave ripples in awake mice are entrained by respiration

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