BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS

Abstract. The data proving low probability of observing Biofilm Formation (BF) by contemporary clinical strains of M. tuberculosis growing on liquid medium in vitro are discussed. A hypothesis about the role of MDR/XDR development hindering BF production was proposed. It was found that strains capab...

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Auteurs principaux:	O. B. Ogarkov, A. E. Suzdalnitsky, P. A. Khromova, T. A. Tsyrenova, N. A. Sokolnikova, S. N. Zhdanova, M. E. Koshcheev
Format:	article
Langue:	RU
Publié:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Sujets:	biofilm production mycobacterium tuberculosis genotypes mdr/xdr Infectious and parasitic diseases RC109-216
Accès en ligne:	https://doaj.org/article/0e58b3a23c874d2aba71d01fd3533c87
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spelling	oai:doaj.org-article:0e58b3a23c874d2aba71d01fd3533c872021-11-22T07:09:52ZBIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2018-4-435-440https://doaj.org/article/0e58b3a23c874d2aba71d01fd3533c872018-12-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/822https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The data proving low probability of observing Biofilm Formation (BF) by contemporary clinical strains of M. tuberculosis growing on liquid medium in vitro are discussed. A hypothesis about the role of MDR/XDR development hindering BF production was proposed. It was found that strains capable of producing BF grow on Lewenstein–Jensen medium generated R-form specific colonies shaped as a disk with a convex center, “UFO-colonies”. Sixty seven “UFO”- strains were investigated to BF production, resistance to antibiotics and their belonging to the main epidemics clusters of the Beijing genotype (CC1 and CC2-W148). It was shown that MDR/XDR strains were also capable of BF production that, however, was remarkably more frequent in strains of CC1 and CC2-W148 genotypes. Thus, it was hypothesized that BF production might potentially influence an outcome of chronic forms of TB-infection.O. B. OgarkovA. E. SuzdalnitskyP. A. KhromovaT. A. TsyrenovaN. A. SokolnikovaS. N. ZhdanovaM. E. KoshcheevSankt-Peterburg : NIIÈM imeni Pasteraarticlebiofilm productionmycobacterium tuberculosisgenotypesmdr/xdrInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 4, Pp 435-440 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	biofilm production mycobacterium tuberculosis genotypes mdr/xdr Infectious and parasitic diseases RC109-216
spellingShingle	biofilm production mycobacterium tuberculosis genotypes mdr/xdr Infectious and parasitic diseases RC109-216 O. B. Ogarkov A. E. Suzdalnitsky P. A. Khromova T. A. Tsyrenova N. A. Sokolnikova S. N. Zhdanova M. E. Koshcheev BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
description	Abstract. The data proving low probability of observing Biofilm Formation (BF) by contemporary clinical strains of M. tuberculosis growing on liquid medium in vitro are discussed. A hypothesis about the role of MDR/XDR development hindering BF production was proposed. It was found that strains capable of producing BF grow on Lewenstein–Jensen medium generated R-form specific colonies shaped as a disk with a convex center, “UFO-colonies”. Sixty seven “UFO”- strains were investigated to BF production, resistance to antibiotics and their belonging to the main epidemics clusters of the Beijing genotype (CC1 and CC2-W148). It was shown that MDR/XDR strains were also capable of BF production that, however, was remarkably more frequent in strains of CC1 and CC2-W148 genotypes. Thus, it was hypothesized that BF production might potentially influence an outcome of chronic forms of TB-infection.
format	article
author	O. B. Ogarkov A. E. Suzdalnitsky P. A. Khromova T. A. Tsyrenova N. A. Sokolnikova S. N. Zhdanova M. E. Koshcheev
author_facet	O. B. Ogarkov A. E. Suzdalnitsky P. A. Khromova T. A. Tsyrenova N. A. Sokolnikova S. N. Zhdanova M. E. Koshcheev
author_sort	O. B. Ogarkov
title	BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
title_short	BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
title_full	BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
title_fullStr	BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
title_full_unstemmed	BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS
title_sort	biofilm formation induced by clinical isolates of mycobacterium tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/0e58b3a23c874d2aba71d01fd3533c87
work_keys_str_mv	AT obogarkov biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT aesuzdalnitsky biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT pakhromova biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT tatsyrenova biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT nasokolnikova biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT snzhdanova biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis AT mekoshcheev biofilmformationinducedbyclinicalisolatesofmycobacteriumtuberculosis
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BIOFILM FORMATION INDUCED BY CLINICAL ISOLATES OF MYCOBACTERIUM TUBERCULOSIS

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