CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.
DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into th...
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Autores principales: | Mariela C Marazita, M Florencia Ogara, Silvina V Sonzogni, Marcelo Martí, Nelson J Dusetti, Omar P Pignataro, Eduardo T Cánepa |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/0e595ffbe060447981e7bb57d4477c2d |
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