A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.
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Nature Portfolio
2017
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oai:doaj.org-article:0e59c496500743b6be34bd70195b16c22021-12-02T17:06:13ZA computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue10.1038/ncomms146622041-1723https://doaj.org/article/0e59c496500743b6be34bd70195b16c22017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14662https://doaj.org/toc/2041-1723The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.Flaminia TalosAntonina MitrofanovaSarah K. BergrenAndrea CalifanoMichael M. ShenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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Science Q Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
description |
The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue. |
format |
article |
author |
Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen |
author_facet |
Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen |
author_sort |
Flaminia Talos |
title |
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
title_short |
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
title_full |
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
title_fullStr |
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
title_full_unstemmed |
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
title_sort |
computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/0e59c496500743b6be34bd70195b16c2 |
work_keys_str_mv |
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