A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.

Guardado en:

Detalles Bibliográficos
Autores principales:	Flaminia Talos, Antonina Mitrofanova, Sarah K. Bergren, Andrea Califano, Michael M. Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e59c496500743b6be34bd70195b16c2
record_format	dspace
spelling	oai:doaj.org-article:0e59c496500743b6be34bd70195b16c22021-12-02T17:06:13ZA computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue10.1038/ncomms146622041-1723https://doaj.org/article/0e59c496500743b6be34bd70195b16c22017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14662https://doaj.org/toc/2041-1723The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.Flaminia TalosAntonina MitrofanovaSarah K. BergrenAndrea CalifanoMichael M. ShenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
description	The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.
format	article
author	Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen
author_facet	Flaminia Talos Antonina Mitrofanova Sarah K. Bergren Andrea Califano Michael M. Shen
author_sort	Flaminia Talos
title	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_short	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_full	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_fullStr	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_full_unstemmed	A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_sort	computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
work_keys_str_mv	AT flaminiatalos acomputationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT antoninamitrofanova acomputationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT sarahkbergren acomputationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT andreacalifano acomputationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT michaelmshen acomputationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT flaminiatalos computationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT antoninamitrofanova computationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT sarahkbergren computationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT andreacalifano computationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue AT michaelmshen computationalsystemsapproachidentifiessynergisticspecificationgenesthatfacilitatelineageconversiontoprostatetissue
_version_	1718381657669500928

A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

Ejemplares similares