A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue

The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.

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Autores principales: Flaminia Talos, Antonina Mitrofanova, Sarah K. Bergren, Andrea Califano, Michael M. Shen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
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spelling oai:doaj.org-article:0e59c496500743b6be34bd70195b16c22021-12-02T17:06:13ZA computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue10.1038/ncomms146622041-1723https://doaj.org/article/0e59c496500743b6be34bd70195b16c22017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14662https://doaj.org/toc/2041-1723The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.Flaminia TalosAntonina MitrofanovaSarah K. BergrenAndrea CalifanoMichael M. ShenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Flaminia Talos
Antonina Mitrofanova
Sarah K. Bergren
Andrea Califano
Michael M. Shen
A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
description The identification of master regulator genes that may be manipulatedin vitro to regulate reprogramming has been difficult. Here, the authors use a computational systems approach to identify three genes (FoxA1, Nkx3.1and the androgen receptor) that can reprogramme fibroblasts to prostate tissue.
format article
author Flaminia Talos
Antonina Mitrofanova
Sarah K. Bergren
Andrea Califano
Michael M. Shen
author_facet Flaminia Talos
Antonina Mitrofanova
Sarah K. Bergren
Andrea Califano
Michael M. Shen
author_sort Flaminia Talos
title A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_short A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_full A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_fullStr A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_full_unstemmed A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
title_sort computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/0e59c496500743b6be34bd70195b16c2
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