Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse mode...

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Autores principales:	Diego Scheggia, Rosa Mastrogiacomo, Maddalena Mereu, Sara Sannino, Richard E. Straub, Marco Armando, Francesca Managò, Simone Guadagna, Fabrizio Piras, Fengyu Zhang, Joel E. Kleinman, Thomas M. Hyde, Sanne S. Kaalund, Maria Pontillo, Genny Orso, Carlo Caltagirone, Emiliana Borrelli, Maria A. De Luca, Stefano Vicari, Daniel R. Weinberger, Gianfranco Spalletta, Francesco Papaleo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e5f124f37b14a83811e7cceee5dc56c
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spelling	oai:doaj.org-article:0e5f124f37b14a83811e7cceee5dc56c2021-12-02T16:56:37ZVariations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment10.1038/s41467-018-04711-w2041-1723https://doaj.org/article/0e5f124f37b14a83811e7cceee5dc56c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04711-whttps://doaj.org/toc/2041-1723Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.Diego ScheggiaRosa MastrogiacomoMaddalena MereuSara SanninoRichard E. StraubMarco ArmandoFrancesca ManagòSimone GuadagnaFabrizio PirasFengyu ZhangJoel E. KleinmanThomas M. HydeSanne S. KaalundMaria PontilloGenny OrsoCarlo CaltagironeEmiliana BorrelliMaria A. De LucaStefano VicariDaniel R. WeinbergerGianfranco SpallettaFrancesco PapaleoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diego Scheggia Rosa Mastrogiacomo Maddalena Mereu Sara Sannino Richard E. Straub Marco Armando Francesca Managò Simone Guadagna Fabrizio Piras Fengyu Zhang Joel E. Kleinman Thomas M. Hyde Sanne S. Kaalund Maria Pontillo Genny Orso Carlo Caltagirone Emiliana Borrelli Maria A. De Luca Stefano Vicari Daniel R. Weinberger Gianfranco Spalletta Francesco Papaleo Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
description	Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models.
format	article
author	Diego Scheggia Rosa Mastrogiacomo Maddalena Mereu Sara Sannino Richard E. Straub Marco Armando Francesca Managò Simone Guadagna Fabrizio Piras Fengyu Zhang Joel E. Kleinman Thomas M. Hyde Sanne S. Kaalund Maria Pontillo Genny Orso Carlo Caltagirone Emiliana Borrelli Maria A. De Luca Stefano Vicari Daniel R. Weinberger Gianfranco Spalletta Francesco Papaleo
author_facet	Diego Scheggia Rosa Mastrogiacomo Maddalena Mereu Sara Sannino Richard E. Straub Marco Armando Francesca Managò Simone Guadagna Fabrizio Piras Fengyu Zhang Joel E. Kleinman Thomas M. Hyde Sanne S. Kaalund Maria Pontillo Genny Orso Carlo Caltagirone Emiliana Borrelli Maria A. De Luca Stefano Vicari Daniel R. Weinberger Gianfranco Spalletta Francesco Papaleo
author_sort	Diego Scheggia
title	Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
title_short	Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
title_full	Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
title_fullStr	Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
title_full_unstemmed	Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
title_sort	variations in dysbindin-1 are associated with cognitive response to antipsychotic drug treatment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e5f124f37b14a83811e7cceee5dc56c
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Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment

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