A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women

Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection condit...

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Autores principales:	Fatemeh Sanie-Jahromi, Yaser NejatyJahromy, Rahim Raoofi Jahromi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 quiescent stem cell active stem cells cell cycle children pregnant women Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/0e5fcfa8aa5941b59715035ff5522cf5
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spelling	oai:doaj.org-article:0e5fcfa8aa5941b59715035ff5522cf52021-11-11T17:14:15ZA Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women10.3390/ijms2221117871422-00671661-6596https://doaj.org/article/0e5fcfa8aa5941b59715035ff5522cf52021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11787https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19.Fatemeh Sanie-JahromiYaser NejatyJahromyRahim Raoofi JahromiMDPI AGarticleCOVID-19quiescent stem cellactive stem cellscell cyclechildrenpregnant womenBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11787, p 11787 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 quiescent stem cell active stem cells cell cycle children pregnant women Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	COVID-19 quiescent stem cell active stem cells cell cycle children pregnant women Biology (General) QH301-705.5 Chemistry QD1-999 Fatemeh Sanie-Jahromi Yaser NejatyJahromy Rahim Raoofi Jahromi A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
description	Since the COVID-19 outbreak was acknowledged by the WHO on 30 January 2020, much research has been conducted to unveil various features of the responsible SARS-CoV-2 virus. Different rates of contagion in adults, children, and pregnant women may guide us to understand the underlying infection conditions of COVID-19. In this study, we first provide a review of recent reports of COVID-19 clinical outcomes in children and pregnant women. We then suggest a mechanism that explains the curious case of COVID-19 in children/pregnant women. The unique stem cell molecular signature, as well as the very low expression of angiotensin-converting enzyme 2 and the lower ACE/ACE2 ratio in stem cells of children/pregnant women compared to adults might be the cause of milder symptoms of COVID-19 in them. This study provides the main molecular keys on how stem cells can function properly and exert their immunomodulatory and regenerative effects in COVID-19-infected children/pregnant women, while failing to replicate their role in adults. This can lay the groundwork for both predicting the pattern of spread and severity of the symptoms in a population and designing novel stem cell-based treatment and prevention strategies for COVID-19.
format	article
author	Fatemeh Sanie-Jahromi Yaser NejatyJahromy Rahim Raoofi Jahromi
author_facet	Fatemeh Sanie-Jahromi Yaser NejatyJahromy Rahim Raoofi Jahromi
author_sort	Fatemeh Sanie-Jahromi
title	A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_short	A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_full	A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_fullStr	A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_full_unstemmed	A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
title_sort	review on the role of stem cells against sars-cov-2 in children and pregnant women
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0e5fcfa8aa5941b59715035ff5522cf5
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A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women

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