Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
Pathogen triggered N-terminal degradation of NLRP1 and CARD8 by the proteasome releases their C-terminal UPA-CARD fragments (CT) to form the inflammasome, which in turn activates caspase-1. Here, the authors present the cryo-EM structures of the NLRP1-CT and CARD8-CT helical filaments as well as the...
Guardado en:
Autores principales: | L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswold, Jianbin Ruan, Humayun Sharif, Pietro Fontana, Elizabeth L. Orth-He, Tian-Min Fu, Daniel A. Bachovchin, Hao Wu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0e61c5714aba4c07951365c347f3e523 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
por: Qin Gong, et al.
Publicado: (2021) -
CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
por: Andrea D'Osualdo, et al.
Publicado: (2011) -
Spotlight on the NLRP3 inflammasome pathway
por: Groslambert M, et al.
Publicado: (2018) -
The role of the NLRP3 inflammasome in gout
por: Sarah R Kingsbury, et al.
Publicado: (2011) -
ADP-Ribosylation of NLRP3 by <named-content content-type="genus-species">Mycoplasma pneumoniae</named-content> CARDS Toxin Regulates Inflammasome Activity
por: Santanu Bose, et al.
Publicado: (2014)