Regulation of the endosomal SNX27-retromer by OTULIN

OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 complex, which reveals a secondary interface th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander, Daniel Krappmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e6312cbac964d7aa65fe7184f4eb189
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e6312cbac964d7aa65fe7184f4eb189
record_format	dspace
spelling	oai:doaj.org-article:0e6312cbac964d7aa65fe7184f4eb1892021-12-02T16:58:28ZRegulation of the endosomal SNX27-retromer by OTULIN10.1038/s41467-019-12309-z2041-1723https://doaj.org/article/0e6312cbac964d7aa65fe7184f4eb1892019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12309-zhttps://doaj.org/toc/2041-1723OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 complex, which reveals a secondary interface through which OTULIN non-catalytically antagonizes SNX27 retromer assembly and cargo loading.Aurelia StanglPaul R. ElliottAdan Pinto-FernandezSarah BonhamLuke HarrisonAnnalisa SchaubKerstin KutznerKirstin KeusekottenPaul T. PflugerFarid El OualidBenedikt M. KesslerDavid KomanderDaniel KrappmannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aurelia Stangl Paul R. Elliott Adan Pinto-Fernandez Sarah Bonham Luke Harrison Annalisa Schaub Kerstin Kutzner Kirstin Keusekotten Paul T. Pfluger Farid El Oualid Benedikt M. Kessler David Komander Daniel Krappmann Regulation of the endosomal SNX27-retromer by OTULIN
description	OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 complex, which reveals a secondary interface through which OTULIN non-catalytically antagonizes SNX27 retromer assembly and cargo loading.
format	article
author	Aurelia Stangl Paul R. Elliott Adan Pinto-Fernandez Sarah Bonham Luke Harrison Annalisa Schaub Kerstin Kutzner Kirstin Keusekotten Paul T. Pfluger Farid El Oualid Benedikt M. Kessler David Komander Daniel Krappmann
author_facet	Aurelia Stangl Paul R. Elliott Adan Pinto-Fernandez Sarah Bonham Luke Harrison Annalisa Schaub Kerstin Kutzner Kirstin Keusekotten Paul T. Pfluger Farid El Oualid Benedikt M. Kessler David Komander Daniel Krappmann
author_sort	Aurelia Stangl
title	Regulation of the endosomal SNX27-retromer by OTULIN
title_short	Regulation of the endosomal SNX27-retromer by OTULIN
title_full	Regulation of the endosomal SNX27-retromer by OTULIN
title_fullStr	Regulation of the endosomal SNX27-retromer by OTULIN
title_full_unstemmed	Regulation of the endosomal SNX27-retromer by OTULIN
title_sort	regulation of the endosomal snx27-retromer by otulin
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0e6312cbac964d7aa65fe7184f4eb189
work_keys_str_mv	AT aureliastangl regulationoftheendosomalsnx27retromerbyotulin AT paulrelliott regulationoftheendosomalsnx27retromerbyotulin AT adanpintofernandez regulationoftheendosomalsnx27retromerbyotulin AT sarahbonham regulationoftheendosomalsnx27retromerbyotulin AT lukeharrison regulationoftheendosomalsnx27retromerbyotulin AT annalisaschaub regulationoftheendosomalsnx27retromerbyotulin AT kerstinkutzner regulationoftheendosomalsnx27retromerbyotulin AT kirstinkeusekotten regulationoftheendosomalsnx27retromerbyotulin AT paultpfluger regulationoftheendosomalsnx27retromerbyotulin AT farideloualid regulationoftheendosomalsnx27retromerbyotulin AT benediktmkessler regulationoftheendosomalsnx27retromerbyotulin AT davidkomander regulationoftheendosomalsnx27retromerbyotulin AT danielkrappmann regulationoftheendosomalsnx27retromerbyotulin
_version_	1718382253000622080

Regulation of the endosomal SNX27-retromer by OTULIN

Ejemplares similares