Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines
Yong Chen,1 Yanjuan Chen,2 Li Zhao,3 Hui He,3 Laiyou Wei,1 Wenjuan Lai,1 Jingxia Yuan,1 Xiaoping Hong,1 Lixiong Liu,1 Baojiang Wang,4 Kutty Selva Nandakumar,5,* Dongzhou Liu1,* 1Division of Rheumatology and Research, The Second Clinical Medical College, Jinan University (Shenzhen Peo...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0e64e1306abd411bb5017f708ed2e02f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0e64e1306abd411bb5017f708ed2e02f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0e64e1306abd411bb5017f708ed2e02f2021-12-02T17:28:08ZAlbumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines1178-7031https://doaj.org/article/0e64e1306abd411bb5017f708ed2e02f2021-10-01T00:00:00Zhttps://www.dovepress.com/albuminglobulin-ratio-as-yinyang-in-rheumatoid-arthritis-and-its-corre-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Yong Chen,1 Yanjuan Chen,2 Li Zhao,3 Hui He,3 Laiyou Wei,1 Wenjuan Lai,1 Jingxia Yuan,1 Xiaoping Hong,1 Lixiong Liu,1 Baojiang Wang,4 Kutty Selva Nandakumar,5,* Dongzhou Liu1,* 1Division of Rheumatology and Research, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of China; 2School of Basic Medicine, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 3Division of Health Management, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of China; 4Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, Guangdong, People’s Republic of China; 5Southern Medical University-Karolinska Institute United Medical Inflammation Center, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongzhou LiuDivision of Rheumatology and Research, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of ChinaTel +86 183 2111 6879Email liu_dz2001@sina.comPurpose: Inflamm-aging is a novel-concept in rheumatoid arthritis (RA) with accelerating aging process. We try to find a correlation between serum albumin/globulin (A/G) ratio and clinical biochemical parameters, incidence of aging-related diseases (ARDs) as well as inflammaging-related molecules.Patients and Methods: Healthy controls (HC) and RA patients were compared with their clinical biochemical parameters including albumin and globulin levels, A/G ratio, and levels of serum lipids. Incidence of ARDs in RA was compared with A/G ratio, having a cut off value of 1.2. Expression levels of leptin and Trf2 genes in PBMCs, and inflammatory factors like IL-1β, IL-6, IL-8 and TNF-ɑ between HC and RA patients were compared, and correlated with the A/G ratio.Results: Compared to HC, RA patients had decreased levels of albumin, while globulin levels were found to be increased, which led to a significantly lower A/G ratio in RA patients. A/G ratio rather than ESR and CRP had significant correlation with dyslipidemia in RA patients. Patients with A/G < 1.2 had a higher risk of ARDs than patients with A/G > 1.2. The RR was 2.48 (95% CI: 1.79 to 3.64, p < 0.0001). In addition, A/G ratio has positively correlated to leptin and Trf2 expression, while an inverse correlation was observed with the levels of inflamm-aging related cytokines like IL-6, IL-8 and TNF-ɑ.Conclusion: A decreased A/G ratio in RA patients has significantly correlated with dyslipidemia and ARDs, as well as inflammaging- related adipokine and pro-inflammatory cytokines. Thus, A/G ratio could be a reliable marker for evaluating the inflammaging process during clinical management in ARDs.Keywords: inflammation, age-related disease, dyslipidemia, leptin, biomarkerChen YChen YZhao LHe HWei LLai WYuan JHong XLiu LWang BNandakumar KSLiu DDove Medical Pressarticleinflammationage-related diseasedyslipidemialeptinbiomarkerPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5501-5511 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
inflammation age-related disease dyslipidemia leptin biomarker Pathology RB1-214 Therapeutics. Pharmacology RM1-950 |
| spellingShingle |
inflammation age-related disease dyslipidemia leptin biomarker Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Chen Y Chen Y Zhao L He H Wei L Lai W Yuan J Hong X Liu L Wang B Nandakumar KS Liu D Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| description |
Yong Chen,1 Yanjuan Chen,2 Li Zhao,3 Hui He,3 Laiyou Wei,1 Wenjuan Lai,1 Jingxia Yuan,1 Xiaoping Hong,1 Lixiong Liu,1 Baojiang Wang,4 Kutty Selva Nandakumar,5,* Dongzhou Liu1,* 1Division of Rheumatology and Research, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of China; 2School of Basic Medicine, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 3Division of Health Management, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of China; 4Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, Guangdong, People’s Republic of China; 5Southern Medical University-Karolinska Institute United Medical Inflammation Center, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dongzhou LiuDivision of Rheumatology and Research, The Second Clinical Medical College, Jinan University (Shenzhen People’s Hospital), Shenzhen, Guangdong, People’s Republic of ChinaTel +86 183 2111 6879Email liu_dz2001@sina.comPurpose: Inflamm-aging is a novel-concept in rheumatoid arthritis (RA) with accelerating aging process. We try to find a correlation between serum albumin/globulin (A/G) ratio and clinical biochemical parameters, incidence of aging-related diseases (ARDs) as well as inflammaging-related molecules.Patients and Methods: Healthy controls (HC) and RA patients were compared with their clinical biochemical parameters including albumin and globulin levels, A/G ratio, and levels of serum lipids. Incidence of ARDs in RA was compared with A/G ratio, having a cut off value of 1.2. Expression levels of leptin and Trf2 genes in PBMCs, and inflammatory factors like IL-1β, IL-6, IL-8 and TNF-ɑ between HC and RA patients were compared, and correlated with the A/G ratio.Results: Compared to HC, RA patients had decreased levels of albumin, while globulin levels were found to be increased, which led to a significantly lower A/G ratio in RA patients. A/G ratio rather than ESR and CRP had significant correlation with dyslipidemia in RA patients. Patients with A/G < 1.2 had a higher risk of ARDs than patients with A/G > 1.2. The RR was 2.48 (95% CI: 1.79 to 3.64, p < 0.0001). In addition, A/G ratio has positively correlated to leptin and Trf2 expression, while an inverse correlation was observed with the levels of inflamm-aging related cytokines like IL-6, IL-8 and TNF-ɑ.Conclusion: A decreased A/G ratio in RA patients has significantly correlated with dyslipidemia and ARDs, as well as inflammaging- related adipokine and pro-inflammatory cytokines. Thus, A/G ratio could be a reliable marker for evaluating the inflammaging process during clinical management in ARDs.Keywords: inflammation, age-related disease, dyslipidemia, leptin, biomarker |
| format |
article |
| author |
Chen Y Chen Y Zhao L He H Wei L Lai W Yuan J Hong X Liu L Wang B Nandakumar KS Liu D |
| author_facet |
Chen Y Chen Y Zhao L He H Wei L Lai W Yuan J Hong X Liu L Wang B Nandakumar KS Liu D |
| author_sort |
Chen Y |
| title |
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| title_short |
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| title_full |
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| title_fullStr |
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| title_full_unstemmed |
Albumin/Globulin Ratio as Yin–Yang in Rheumatoid Arthritis and Its Correlation to Inflamm-Aging Cytokines |
| title_sort |
albumin/globulin ratio as yin–yang in rheumatoid arthritis and its correlation to inflamm-aging cytokines |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/0e64e1306abd411bb5017f708ed2e02f |
| work_keys_str_mv |
AT cheny albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT cheny albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT zhaol albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT heh albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT weil albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT laiw albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT yuanj albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT hongx albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT liul albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT wangb albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT nandakumarks albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines AT liud albuminglobulinratioasyinndashyanginrheumatoidarthritisanditscorrelationtoinflammagingcytokines |
| _version_ |
1718380716311445504 |