Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

How antibody reaches tissues from circulation is critical for understanding antibody-mediated immunity. Here the authors show that IgG extravasation in the skin is mediated by endothelial caveolin transport independently of FcR, and is targetable by imatinib, which reduces IgG-dependent pathology in...

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Autores principales:	Sachiko Ono, Gyohei Egawa, Takashi Nomura, Akihiko Kitoh, Teruki Dainichi, Atsushi Otsuka, Saeko Nakajima, Masayuki Amagai, Fumi Matsumoto, Mami Yamamoto, Yoshiaki Kubota, Toshiyuki Takai, Tetsuya Honda, Kenji Kabashima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e6630e6d7374fc5b6b9786d0dca5740
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spelling	oai:doaj.org-article:0e6630e6d7374fc5b6b9786d0dca57402021-12-02T17:01:47ZAbl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model10.1038/s41467-019-12232-32041-1723https://doaj.org/article/0e6630e6d7374fc5b6b9786d0dca57402019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12232-3https://doaj.org/toc/2041-1723How antibody reaches tissues from circulation is critical for understanding antibody-mediated immunity. Here the authors show that IgG extravasation in the skin is mediated by endothelial caveolin transport independently of FcR, and is targetable by imatinib, which reduces IgG-dependent pathology in a mouse model of pemphigus.Sachiko OnoGyohei EgawaTakashi NomuraAkihiko KitohTeruki DainichiAtsushi OtsukaSaeko NakajimaMasayuki AmagaiFumi MatsumotoMami YamamotoYoshiaki KubotaToshiyuki TakaiTetsuya HondaKenji KabashimaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sachiko Ono Gyohei Egawa Takashi Nomura Akihiko Kitoh Teruki Dainichi Atsushi Otsuka Saeko Nakajima Masayuki Amagai Fumi Matsumoto Mami Yamamoto Yoshiaki Kubota Toshiyuki Takai Tetsuya Honda Kenji Kabashima Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
description	How antibody reaches tissues from circulation is critical for understanding antibody-mediated immunity. Here the authors show that IgG extravasation in the skin is mediated by endothelial caveolin transport independently of FcR, and is targetable by imatinib, which reduces IgG-dependent pathology in a mouse model of pemphigus.
format	article
author	Sachiko Ono Gyohei Egawa Takashi Nomura Akihiko Kitoh Teruki Dainichi Atsushi Otsuka Saeko Nakajima Masayuki Amagai Fumi Matsumoto Mami Yamamoto Yoshiaki Kubota Toshiyuki Takai Tetsuya Honda Kenji Kabashima
author_facet	Sachiko Ono Gyohei Egawa Takashi Nomura Akihiko Kitoh Teruki Dainichi Atsushi Otsuka Saeko Nakajima Masayuki Amagai Fumi Matsumoto Mami Yamamoto Yoshiaki Kubota Toshiyuki Takai Tetsuya Honda Kenji Kabashima
author_sort	Sachiko Ono
title	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
title_short	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
title_full	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
title_fullStr	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
title_full_unstemmed	Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model
title_sort	abl family tyrosine kinases govern igg extravasation in the skin in a murine pemphigus model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0e6630e6d7374fc5b6b9786d0dca5740
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Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

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