A myostatin-CCL20–CCR6 axis regulates Th17 cell recruitment to inflamed joints in experimental arthritis
Abstract The interactions of fibroblast-like synoviocyte (FLS)-derived pro-inflammatory cytokines/chemokines and immune cells support the recruitment and activation of inflammatory cells in RA. Here, we show for the first time that the classical myokine myostatin (GDF-8) is involved in the recruitme...
Guardado en:
Autores principales: | Michelle Fennen, Toni Weinhage, Vanessa Kracke, Johanna Intemann, Georg Varga, Corinna Wehmeyer, Dirk Foell, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/0e68a05c59a446c9abd58a77cfaf8633 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Peripheral monocyte functions and activation in patients with quiescent Crohn's disease.
por: David Schwarzmaier, et al.
Publicado: (2013) -
Ccl2/Ccr2 signalling recruits a distinct fetal microchimeric population that rescues delayed maternal wound healing
por: Mathieu Castela, et al.
Publicado: (2017) -
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
por: Denise Beckmann, et al.
Publicado: (2021) -
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
por: Claudia M. Wunderlich, et al.
Publicado: (2018) -
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
por: David Jonathan Wasilko, et al.
Publicado: (2020)