Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by FGF21 signalling and oxytocin.

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Autores principales:	Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f1
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spelling	oai:doaj.org-article:0e6908642176438fbd24e41a6c8e07f12021-12-02T15:34:06ZNeuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice10.1038/s41467-018-07033-z2041-1723https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f12018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07033-zhttps://doaj.org/toc/2041-1723SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by FGF21 signalling and oxytocin.Sho MatsuiTsutomu SasakiDaisuke KohnoKeisuke YakuAyumu InutsukaHiromi Yokota-HashimotoOsamu KikuchiTakayoshi SugaMasaki KobayashiAkihiro YamanakaAkihiro HaradaTakashi NakagawaTatsushi OnakaTadahiro KitamuraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sho Matsui Tsutomu Sasaki Daisuke Kohno Keisuke Yaku Ayumu Inutsuka Hiromi Yokota-Hashimoto Osamu Kikuchi Takayoshi Suga Masaki Kobayashi Akihiro Yamanaka Akihiro Harada Takashi Nakagawa Tatsushi Onaka Tadahiro Kitamura Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
description	SIRT1 is a NAD+-dependent deacetylase whose functions have been linked to organismal longevity, aging and metabolism. Here, Matsui and colleagues show that neuronal SIRT1 can affect nutrient-related dietary choice in mice, and this effect is mediated by FGF21 signalling and oxytocin.
format	article
author	Sho Matsui Tsutomu Sasaki Daisuke Kohno Keisuke Yaku Ayumu Inutsuka Hiromi Yokota-Hashimoto Osamu Kikuchi Takayoshi Suga Masaki Kobayashi Akihiro Yamanaka Akihiro Harada Takashi Nakagawa Tatsushi Onaka Tadahiro Kitamura
author_facet	Sho Matsui Tsutomu Sasaki Daisuke Kohno Keisuke Yaku Ayumu Inutsuka Hiromi Yokota-Hashimoto Osamu Kikuchi Takayoshi Suga Masaki Kobayashi Akihiro Yamanaka Akihiro Harada Takashi Nakagawa Tatsushi Onaka Tadahiro Kitamura
author_sort	Sho Matsui
title	Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
title_short	Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
title_full	Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
title_fullStr	Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
title_full_unstemmed	Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
title_sort	neuronal sirt1 regulates macronutrient-based diet selection through fgf21 and oxytocin signalling in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e6908642176438fbd24e41a6c8e07f1
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Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

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