SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryon...

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Autores principales:	Parysatis Sachs, Dong Ding, Philipp Bergmaier, Boris Lamp, Christina Schlagheck, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Jacqueline E. Mermoud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e710344df08499391e740770a34e858
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spelling	oai:doaj.org-article:0e710344df08499391e740770a34e8582021-12-02T14:39:20ZSMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells10.1038/s41467-019-09078-02041-1723https://doaj.org/article/0e710344df08499391e740770a34e8582019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09078-0https://doaj.org/toc/2041-1723Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.Parysatis SachsDong DingPhilipp BergmaierBoris LampChristina SchlagheckFlorian FinkernagelAndrea NistThorsten StieweJacqueline E. MermoudNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Parysatis Sachs Dong Ding Philipp Bergmaier Boris Lamp Christina Schlagheck Florian Finkernagel Andrea Nist Thorsten Stiewe Jacqueline E. Mermoud SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
description	Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryonic stem cells.
format	article
author	Parysatis Sachs Dong Ding Philipp Bergmaier Boris Lamp Christina Schlagheck Florian Finkernagel Andrea Nist Thorsten Stiewe Jacqueline E. Mermoud
author_facet	Parysatis Sachs Dong Ding Philipp Bergmaier Boris Lamp Christina Schlagheck Florian Finkernagel Andrea Nist Thorsten Stiewe Jacqueline E. Mermoud
author_sort	Parysatis Sachs
title	SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_short	SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_full	SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_fullStr	SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_full_unstemmed	SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
title_sort	smarcad1 atpase activity is required to silence endogenous retroviruses in embryonic stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0e710344df08499391e740770a34e858
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SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

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