SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Tight regulation of retrotransposons such as endogenous retroviruses (ERVs) is essential for genome and transcriptome integrity. Here, the authors show that the ATPase function of the chromatin remodeler SMARCAD1 facilitates the binding of KAP1 to ERVs and is required for their repression in embryon...

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Autores principales: Parysatis Sachs, Dong Ding, Philipp Bergmaier, Boris Lamp, Christina Schlagheck, Florian Finkernagel, Andrea Nist, Thorsten Stiewe, Jacqueline E. Mermoud
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0e710344df08499391e740770a34e858
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