Act1 is a negative regulator in T and B cells via direct inhibition of STAT3
Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/0e7548ce23cd448eb502abafb308eb2a |
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oai:doaj.org-article:0e7548ce23cd448eb502abafb308eb2a2021-12-02T17:32:30ZAct1 is a negative regulator in T and B cells via direct inhibition of STAT310.1038/s41467-018-04974-32041-1723https://doaj.org/article/0e7548ce23cd448eb502abafb308eb2a2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04974-3https://doaj.org/toc/2041-1723Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3.Cun-Jin ZhangChenhui WangMeiling JiangChunfang GuJianxin XiaoXing ChenBradley N. MartinFangqiang TangErin YamamotoYibo XianHan WangFengling LiR. Balfour SartorHoward SmithM. Elaine HusniFu-Dong ShiJi GaoJulie CarmanAshok DongreSusan C. McKarnsKen CoppietersTrine N. JørgensenWarren J. LeonardXiaoxia LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Cun-Jin Zhang Chenhui Wang Meiling Jiang Chunfang Gu Jianxin Xiao Xing Chen Bradley N. Martin Fangqiang Tang Erin Yamamoto Yibo Xian Han Wang Fengling Li R. Balfour Sartor Howard Smith M. Elaine Husni Fu-Dong Shi Ji Gao Julie Carman Ashok Dongre Susan C. McKarns Ken Coppieters Trine N. Jørgensen Warren J. Leonard Xiaoxia Li Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| description |
Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3. |
| format |
article |
| author |
Cun-Jin Zhang Chenhui Wang Meiling Jiang Chunfang Gu Jianxin Xiao Xing Chen Bradley N. Martin Fangqiang Tang Erin Yamamoto Yibo Xian Han Wang Fengling Li R. Balfour Sartor Howard Smith M. Elaine Husni Fu-Dong Shi Ji Gao Julie Carman Ashok Dongre Susan C. McKarns Ken Coppieters Trine N. Jørgensen Warren J. Leonard Xiaoxia Li |
| author_facet |
Cun-Jin Zhang Chenhui Wang Meiling Jiang Chunfang Gu Jianxin Xiao Xing Chen Bradley N. Martin Fangqiang Tang Erin Yamamoto Yibo Xian Han Wang Fengling Li R. Balfour Sartor Howard Smith M. Elaine Husni Fu-Dong Shi Ji Gao Julie Carman Ashok Dongre Susan C. McKarns Ken Coppieters Trine N. Jørgensen Warren J. Leonard Xiaoxia Li |
| author_sort |
Cun-Jin Zhang |
| title |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| title_short |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| title_full |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| title_fullStr |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| title_full_unstemmed |
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 |
| title_sort |
act1 is a negative regulator in t and b cells via direct inhibition of stat3 |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0e7548ce23cd448eb502abafb308eb2a |
| work_keys_str_mv |
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