Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

Abstract Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-rece...

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Autores principales:	Rene Barro-Soria, Alejandro Caicedo, Herbert Jägle, Laura Merkel, Na Zhao, Gabriel Knop, Kaspar Gierke, Andrea Dannullis, Hayo Castrop, Johann Helmut Brandstätter, Frank Kirchhoff, Andreas Feigenspan, Olaf Strauß
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e7bea7f490544e5b2646f64c985bf98
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spelling	oai:doaj.org-article:0e7bea7f490544e5b2646f64c985bf982021-12-02T13:35:11ZAngiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells10.1038/s41598-019-55380-82045-2322https://doaj.org/article/0e7bea7f490544e5b2646f64c985bf982019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-55380-8https://doaj.org/toc/2045-2322Abstract Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca2+ transients. Compared to wild type, Ca2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca2+-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca2+ signaling within the central nervous system.Rene Barro-SoriaAlejandro CaicedoHerbert JägleLaura MerkelNa ZhaoGabriel KnopKaspar GierkeAndrea DannullisHayo CastropJohann Helmut BrandstätterFrank KirchhoffAndreas FeigenspanOlaf StraußNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rene Barro-Soria Alejandro Caicedo Herbert Jägle Laura Merkel Na Zhao Gabriel Knop Kaspar Gierke Andrea Dannullis Hayo Castrop Johann Helmut Brandstätter Frank Kirchhoff Andreas Feigenspan Olaf Strauß Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
description	Abstract Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully understood. Here, we show that the angiotensin-receptor-associated protein (ATRAP) localizes to synaptic terminals throughout the central nervous system. In the retinal photoreceptor synapse and the cerebellar mossy fiber-granule cell synapse, we find that ATRAP is involved in the generation of depolarization-evoked synaptic Ca2+ transients. Compared to wild type, Ca2+ imaging in acutely isolated preparations of the retina and the cerebellum from ATRAP knockout mice reveals a significant reduction of the sarcoendoplasmic reticulum (SR) Ca2+-ATPase (SERCA) activity. Thus, in addition to its conventional role in angiotensin signaling, ATRAP also modulates presynaptic Ca2+ signaling within the central nervous system.
format	article
author	Rene Barro-Soria Alejandro Caicedo Herbert Jägle Laura Merkel Na Zhao Gabriel Knop Kaspar Gierke Andrea Dannullis Hayo Castrop Johann Helmut Brandstätter Frank Kirchhoff Andreas Feigenspan Olaf Strauß
author_facet	Rene Barro-Soria Alejandro Caicedo Herbert Jägle Laura Merkel Na Zhao Gabriel Knop Kaspar Gierke Andrea Dannullis Hayo Castrop Johann Helmut Brandstätter Frank Kirchhoff Andreas Feigenspan Olaf Strauß
author_sort	Rene Barro-Soria
title	Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
title_short	Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
title_full	Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
title_fullStr	Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
title_full_unstemmed	Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells
title_sort	angiotensin-receptor-associated protein modulates ca2+ signals in photoreceptor and mossy fiber cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0e7bea7f490544e5b2646f64c985bf98
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Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

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