Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making

Abstract The peritoneal cavity is the second commonest site of mesothelioma after the pleural cavity. There are five histological types of peritoneal mesothelioma with variable symptomatology, clinical presentation and prognosis. Cystic mesothelioma is a borderline malignant neoplasm with a favourab...

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Autores principales:	Anuradha Chandramohan, Nehal Shah, Andrew Thrower, Norman John Carr, Rohin Mittal, Faheez Mohamed, Brendan Moran
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Peritoneal mesothelioma Complete cytoreduction Radiological peritoneal cancer index PAUSE Imaging Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/0e7e5417a8be46bc8d3c584968a6df4b
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spelling	oai:doaj.org-article:0e7e5417a8be46bc8d3c584968a6df4b2021-11-28T12:08:47ZCommunicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making10.1186/s13244-021-01118-y1869-4101https://doaj.org/article/0e7e5417a8be46bc8d3c584968a6df4b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01118-yhttps://doaj.org/toc/1869-4101Abstract The peritoneal cavity is the second commonest site of mesothelioma after the pleural cavity. There are five histological types of peritoneal mesothelioma with variable symptomatology, clinical presentation and prognosis. Cystic mesothelioma is a borderline malignant neoplasm with a favourable prognosis, well-differentiated papillary mesothelioma is generally a low-grade malignancy, and all other varieties such as epithelioid, sarcomatoid and biphasic mesothelioma are highly malignant types of peritoneal mesothelioma with poor prognosis. Malignant peritoneal mesothelioma was considered inevitably fatal prior to the introduction of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in selected cases where long-term survival and cure could be achieved. However, the survival benefits following CRS and HIPEC mainly depend on completeness of cytoreduction, which come at the cost of high morbidity and potential mortality. Using the acronym ‘PAUSE’, we aimed at describing the key imaging findings that impact surgical decision-making in patients with peritoneal mesothelioma. PAUSE stands for peritoneal cancer index, ascites and abdominal wall disease, unfavourable sites of involvement, small bowel and mesenteric disease and extraperitoneal disease. Reporting components of ‘PAUSE’ is crucial for patient selection. Despite limitations of CT in accurately depicting the volume of disease, describing findings in terms of PAUSE plays an important role in excluding patients who might not benefit from CRS and HIPEC.Anuradha ChandramohanNehal ShahAndrew ThrowerNorman John CarrRohin MittalFaheez MohamedBrendan MoranSpringerOpenarticlePeritoneal mesotheliomaComplete cytoreductionRadiological peritoneal cancer indexPAUSEImagingMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Peritoneal mesothelioma Complete cytoreduction Radiological peritoneal cancer index PAUSE Imaging Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Peritoneal mesothelioma Complete cytoreduction Radiological peritoneal cancer index PAUSE Imaging Medical physics. Medical radiology. Nuclear medicine R895-920 Anuradha Chandramohan Nehal Shah Andrew Thrower Norman John Carr Rohin Mittal Faheez Mohamed Brendan Moran Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
description	Abstract The peritoneal cavity is the second commonest site of mesothelioma after the pleural cavity. There are five histological types of peritoneal mesothelioma with variable symptomatology, clinical presentation and prognosis. Cystic mesothelioma is a borderline malignant neoplasm with a favourable prognosis, well-differentiated papillary mesothelioma is generally a low-grade malignancy, and all other varieties such as epithelioid, sarcomatoid and biphasic mesothelioma are highly malignant types of peritoneal mesothelioma with poor prognosis. Malignant peritoneal mesothelioma was considered inevitably fatal prior to the introduction of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in selected cases where long-term survival and cure could be achieved. However, the survival benefits following CRS and HIPEC mainly depend on completeness of cytoreduction, which come at the cost of high morbidity and potential mortality. Using the acronym ‘PAUSE’, we aimed at describing the key imaging findings that impact surgical decision-making in patients with peritoneal mesothelioma. PAUSE stands for peritoneal cancer index, ascites and abdominal wall disease, unfavourable sites of involvement, small bowel and mesenteric disease and extraperitoneal disease. Reporting components of ‘PAUSE’ is crucial for patient selection. Despite limitations of CT in accurately depicting the volume of disease, describing findings in terms of PAUSE plays an important role in excluding patients who might not benefit from CRS and HIPEC.
format	article
author	Anuradha Chandramohan Nehal Shah Andrew Thrower Norman John Carr Rohin Mittal Faheez Mohamed Brendan Moran
author_facet	Anuradha Chandramohan Nehal Shah Andrew Thrower Norman John Carr Rohin Mittal Faheez Mohamed Brendan Moran
author_sort	Anuradha Chandramohan
title	Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
title_short	Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
title_full	Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
title_fullStr	Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
title_full_unstemmed	Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making
title_sort	communicating imaging findings in peritoneal mesothelioma: the impact of ‘pause’ on surgical decision-making
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/0e7e5417a8be46bc8d3c584968a6df4b
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Communicating imaging findings in peritoneal mesothelioma: the impact of ‘PAUSE’ on surgical decision-making

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