Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

ATP can activate a variety of pathways through P2 purinoreceptors, leading to neuroprotection and pathology in the CNS. Among all P2X receptors, the P2X7 receptor (P2X7R) is a well-defined therapeutic target for inflammatory and neuropathic pain. Activation of P2X7R can generate reactive oxygen spec...

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Autores principales: Frances M. Munoz, Ruby Gao, Yuzhen Tian, Brian A. Henstenburg, James E. Barrett, Huijuan Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/0e7fa1811f9241d196231637c0a5d104
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