Physical basis of amyloid fibril polymorphism

Amyloid fibril structures can display polymorphism. Here the authors reveal the cryo-EM structures of several different fibril morphologies of a peptide derived from an amyloidogenic immunoglobulin light chain and present a mathematical analysis of physical factors that influence fibril polymorphism...

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Autores principales:	William Close, Matthias Neumann, Andreas Schmidt, Manuel Hora, Karthikeyan Annamalai, Matthias Schmidt, Bernd Reif, Volker Schmidt, Nikolaus Grigorieff, Marcus Fändrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e804c5e89db443289443ff9451e6c39
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spelling	oai:doaj.org-article:0e804c5e89db443289443ff9451e6c392021-12-02T16:56:54ZPhysical basis of amyloid fibril polymorphism10.1038/s41467-018-03164-52041-1723https://doaj.org/article/0e804c5e89db443289443ff9451e6c392018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03164-5https://doaj.org/toc/2041-1723Amyloid fibril structures can display polymorphism. Here the authors reveal the cryo-EM structures of several different fibril morphologies of a peptide derived from an amyloidogenic immunoglobulin light chain and present a mathematical analysis of physical factors that influence fibril polymorphism.William CloseMatthias NeumannAndreas SchmidtManuel HoraKarthikeyan AnnamalaiMatthias SchmidtBernd ReifVolker SchmidtNikolaus GrigorieffMarcus FändrichNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William Close Matthias Neumann Andreas Schmidt Manuel Hora Karthikeyan Annamalai Matthias Schmidt Bernd Reif Volker Schmidt Nikolaus Grigorieff Marcus Fändrich Physical basis of amyloid fibril polymorphism
description	Amyloid fibril structures can display polymorphism. Here the authors reveal the cryo-EM structures of several different fibril morphologies of a peptide derived from an amyloidogenic immunoglobulin light chain and present a mathematical analysis of physical factors that influence fibril polymorphism.
format	article
author	William Close Matthias Neumann Andreas Schmidt Manuel Hora Karthikeyan Annamalai Matthias Schmidt Bernd Reif Volker Schmidt Nikolaus Grigorieff Marcus Fändrich
author_facet	William Close Matthias Neumann Andreas Schmidt Manuel Hora Karthikeyan Annamalai Matthias Schmidt Bernd Reif Volker Schmidt Nikolaus Grigorieff Marcus Fändrich
author_sort	William Close
title	Physical basis of amyloid fibril polymorphism
title_short	Physical basis of amyloid fibril polymorphism
title_full	Physical basis of amyloid fibril polymorphism
title_fullStr	Physical basis of amyloid fibril polymorphism
title_full_unstemmed	Physical basis of amyloid fibril polymorphism
title_sort	physical basis of amyloid fibril polymorphism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e804c5e89db443289443ff9451e6c39
work_keys_str_mv	AT williamclose physicalbasisofamyloidfibrilpolymorphism AT matthiasneumann physicalbasisofamyloidfibrilpolymorphism AT andreasschmidt physicalbasisofamyloidfibrilpolymorphism AT manuelhora physicalbasisofamyloidfibrilpolymorphism AT karthikeyanannamalai physicalbasisofamyloidfibrilpolymorphism AT matthiasschmidt physicalbasisofamyloidfibrilpolymorphism AT berndreif physicalbasisofamyloidfibrilpolymorphism AT volkerschmidt physicalbasisofamyloidfibrilpolymorphism AT nikolausgrigorieff physicalbasisofamyloidfibrilpolymorphism AT marcusfandrich physicalbasisofamyloidfibrilpolymorphism
_version_	1718382664294072320

Physical basis of amyloid fibril polymorphism

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