Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

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Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

ABSTRACT The gut microbiota modulates obesity and associated metabolic phenotypes in part through intestinal farnesoid X receptor (FXR) signaling. Glycine-β-muricholic acid (Gly-MCA), an intestinal FXR antagonist, has been reported to prevent or reverse high-fat diet (HFD)-induced and genetic obesit...

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Auteurs principaux:	Limin Zhang, Cen Xie, Robert G. Nichols, Siu H. J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2016
Sujets:	bile acid farnesoid X receptor genome-scale metabolic models gut microbiota metabolomics nonalcoholic fatty liver disease Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/0e83188a77784a3c912625c3860b0e97
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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