Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

ABSTRACT The gut microbiota modulates obesity and associated metabolic phenotypes in part through intestinal farnesoid X receptor (FXR) signaling. Glycine-β-muricholic acid (Gly-MCA), an intestinal FXR antagonist, has been reported to prevent or reverse high-fat diet (HFD)-induced and genetic obesit...

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Bibliographic Details
Main Authors: Limin Zhang, Cen Xie, Robert G. Nichols, Siu H. J. Chan, Changtao Jiang, Ruixin Hao, Philip B. Smith, Jingwei Cai, Margaret N. Simons, Emmanuel Hatzakis, Costas D. Maranas, Frank J. Gonzalez, Andrew D. Patterson
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
bile acid
farnesoid X receptor
genome-scale metabolic models
gut microbiota
metabolomics
nonalcoholic fatty liver disease
Microbiology
QR1-502
Online Access:https://doaj.org/article/0e83188a77784a3c912625c3860b0e97
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