Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).

Vascular reactivity (VR), defined as blood vessels' capability to actively modify the diameter and flow resistances can be non-invasively assessed analyzing vascular response to forearm occlusion. Several VR indexes can be quantified: (i) ´microvascular´, which consider variables that depend al...

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Autores principales:	Yanina Zócalo, Daniel Bia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e83bfbf0b174dd6925c3fed5c83b91d
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spelling	oai:doaj.org-article:0e83bfbf0b174dd6925c3fed5c83b91d2021-12-02T20:06:49ZAge- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).1932-620310.1371/journal.pone.0254869https://doaj.org/article/0e83bfbf0b174dd6925c3fed5c83b91d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254869https://doaj.org/toc/1932-6203Vascular reactivity (VR), defined as blood vessels' capability to actively modify the diameter and flow resistances can be non-invasively assessed analyzing vascular response to forearm occlusion. Several VR indexes can be quantified: (i) ´microvascular´, which consider variables that depend almost exclusively on changes in distal resistances, (ii)´ macrovascular´, that evaluate the changes in brachial artery (BA) diameter, adjusting for blood flow stimulus, and (iii) ´macro/micro´, whose values depend on the micro and macrovascular response without discriminating each one´s contribution. VR indexes could not be associated. Many VR indexes have been used without availability of adequate normative data (reference intervals, RIs).<h4>Aims</h4>(1) to evaluate macro, macro/micro and micro VR indexes obtained in a cohort of healthy children, adolescents and adults, (2) to evaluate the association between VR indexes, (3) to determine the need for age and/or sex-specific RIs, and (4) to define RIs for VR indexes.<h4>Methods</h4>Ultrasound (B-mode/Doppler) and automatic computerized analysis were used to assess BA diameter, blood flow velocity and distal resistances, at rest and in conditions of decreased and increased blood flow. Macro, macro/micro and micro VR indexes were quantified (n = 3619). RIs-subgroups were defined according to European Reference Values for Arterial Measurements Collaboration Group (n = 1688, 3-84 years) and HUNT3-Fitness Study Group (n = 2609, 3-85 years) criteria. Mean value and standard deviation equations were obtained for VR indexes. The need for age or sex-specific RIs was analyzed. Percentile curves were defined and data were compared with those obtained in other populations.<h4>Conclusion</h4>Macro and macro/micro VR indexes showed no association (or it was very weak) with microvascular indexes. Age- and sex-related profiles and RIs for macro, macro/micro and micro VR indexes were defined in a large population of healthy subjects (3-85 y). Equations for mean, standard deviation and percentiles values (year-to-year) were included in text and spreadsheet formats.Yanina ZócaloDaniel BiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254869 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yanina Zócalo Daniel Bia Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
description	Vascular reactivity (VR), defined as blood vessels' capability to actively modify the diameter and flow resistances can be non-invasively assessed analyzing vascular response to forearm occlusion. Several VR indexes can be quantified: (i) ´microvascular´, which consider variables that depend almost exclusively on changes in distal resistances, (ii)´ macrovascular´, that evaluate the changes in brachial artery (BA) diameter, adjusting for blood flow stimulus, and (iii) ´macro/micro´, whose values depend on the micro and macrovascular response without discriminating each one´s contribution. VR indexes could not be associated. Many VR indexes have been used without availability of adequate normative data (reference intervals, RIs).<h4>Aims</h4>(1) to evaluate macro, macro/micro and micro VR indexes obtained in a cohort of healthy children, adolescents and adults, (2) to evaluate the association between VR indexes, (3) to determine the need for age and/or sex-specific RIs, and (4) to define RIs for VR indexes.<h4>Methods</h4>Ultrasound (B-mode/Doppler) and automatic computerized analysis were used to assess BA diameter, blood flow velocity and distal resistances, at rest and in conditions of decreased and increased blood flow. Macro, macro/micro and micro VR indexes were quantified (n = 3619). RIs-subgroups were defined according to European Reference Values for Arterial Measurements Collaboration Group (n = 1688, 3-84 years) and HUNT3-Fitness Study Group (n = 2609, 3-85 years) criteria. Mean value and standard deviation equations were obtained for VR indexes. The need for age or sex-specific RIs was analyzed. Percentile curves were defined and data were compared with those obtained in other populations.<h4>Conclusion</h4>Macro and macro/micro VR indexes showed no association (or it was very weak) with microvascular indexes. Age- and sex-related profiles and RIs for macro, macro/micro and micro VR indexes were defined in a large population of healthy subjects (3-85 y). Equations for mean, standard deviation and percentiles values (year-to-year) were included in text and spreadsheet formats.
format	article
author	Yanina Zócalo Daniel Bia
author_facet	Yanina Zócalo Daniel Bia
author_sort	Yanina Zócalo
title	Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
title_short	Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
title_full	Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
title_fullStr	Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
title_full_unstemmed	Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).
title_sort	age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: association between indexes and normative data from 2609 healthy subjects (3-85 years).
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0e83bfbf0b174dd6925c3fed5c83b91d
work_keys_str_mv	AT yaninazocalo ageandsexrelatedprofilesformacromacromicroandmicrovascularreactivityindexesassociationbetweenindexesandnormativedatafrom2609healthysubjects385years AT danielbia ageandsexrelatedprofilesformacromacromicroandmicrovascularreactivityindexesassociationbetweenindexesandnormativedatafrom2609healthysubjects385years
_version_	1718375345078403072

Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years).

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