P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

P2X7 receptors are purinergic receptors with pro-inflammatory functions. Here, the authors show that inhibition of leukocyte P2X7 receptors reduces dendritic spine pathology and social behavioral deficits in a mouse model of Rett syndrome.

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Autores principales: Juan Mauricio Garré, Hernandez Moura Silva, Juan J. Lafaille, Guang Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0e8545eb2716481fa8f38410a3a24538
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spelling oai:doaj.org-article:0e8545eb2716481fa8f38410a3a245382021-12-02T16:50:01ZP2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice10.1038/s41467-020-15590-52041-1723https://doaj.org/article/0e8545eb2716481fa8f38410a3a245382020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15590-5https://doaj.org/toc/2041-1723P2X7 receptors are purinergic receptors with pro-inflammatory functions. Here, the authors show that inhibition of leukocyte P2X7 receptors reduces dendritic spine pathology and social behavioral deficits in a mouse model of Rett syndrome.Juan Mauricio GarréHernandez Moura SilvaJuan J. LafailleGuang YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Juan Mauricio Garré
Hernandez Moura Silva
Juan J. Lafaille
Guang Yang
P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
description P2X7 receptors are purinergic receptors with pro-inflammatory functions. Here, the authors show that inhibition of leukocyte P2X7 receptors reduces dendritic spine pathology and social behavioral deficits in a mouse model of Rett syndrome.
format article
author Juan Mauricio Garré
Hernandez Moura Silva
Juan J. Lafaille
Guang Yang
author_facet Juan Mauricio Garré
Hernandez Moura Silva
Juan J. Lafaille
Guang Yang
author_sort Juan Mauricio Garré
title P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
title_short P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
title_full P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
title_fullStr P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
title_full_unstemmed P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
title_sort p2x7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in rett syndrome mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0e8545eb2716481fa8f38410a3a24538
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AT hernandezmourasilva p2x7receptorinhibitionamelioratesdendriticspinepathologyandsocialbehavioraldeficitsinrettsyndromemice
AT juanjlafaille p2x7receptorinhibitionamelioratesdendriticspinepathologyandsocialbehavioraldeficitsinrettsyndromemice
AT guangyang p2x7receptorinhibitionamelioratesdendriticspinepathologyandsocialbehavioraldeficitsinrettsyndromemice
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