Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids

Asymmetric activation of amide bonds remains a challenge due to the high stability of amide linkages. Here, the authors show an organocatalytic asymmetric C-N bond cleavage of N-sulfonyl biaryl lactams under mild conditions, to access axially chiral biaryl amino acids.

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Autores principales:	Guanjie Wang, Qianqian Shi, Wanyao Hu, Tao Chen, Yingying Guo, Zhouli Hu, Minghua Gong, Jingcheng Guo, Donghui Wei, Zhenqian Fu, Wei Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e8677445c7f41fa85cca6126fbd741e
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spelling	oai:doaj.org-article:0e8677445c7f41fa85cca6126fbd741e2021-12-02T15:39:20ZOrganocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids10.1038/s41467-020-14799-82041-1723https://doaj.org/article/0e8677445c7f41fa85cca6126fbd741e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14799-8https://doaj.org/toc/2041-1723Asymmetric activation of amide bonds remains a challenge due to the high stability of amide linkages. Here, the authors show an organocatalytic asymmetric C-N bond cleavage of N-sulfonyl biaryl lactams under mild conditions, to access axially chiral biaryl amino acids.Guanjie WangQianqian ShiWanyao HuTao ChenYingying GuoZhouli HuMinghua GongJingcheng GuoDonghui WeiZhenqian FuWei HuangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guanjie Wang Qianqian Shi Wanyao Hu Tao Chen Yingying Guo Zhouli Hu Minghua Gong Jingcheng Guo Donghui Wei Zhenqian Fu Wei Huang Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
description	Asymmetric activation of amide bonds remains a challenge due to the high stability of amide linkages. Here, the authors show an organocatalytic asymmetric C-N bond cleavage of N-sulfonyl biaryl lactams under mild conditions, to access axially chiral biaryl amino acids.
format	article
author	Guanjie Wang Qianqian Shi Wanyao Hu Tao Chen Yingying Guo Zhouli Hu Minghua Gong Jingcheng Guo Donghui Wei Zhenqian Fu Wei Huang
author_facet	Guanjie Wang Qianqian Shi Wanyao Hu Tao Chen Yingying Guo Zhouli Hu Minghua Gong Jingcheng Guo Donghui Wei Zhenqian Fu Wei Huang
author_sort	Guanjie Wang
title	Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
title_short	Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
title_full	Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
title_fullStr	Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
title_full_unstemmed	Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
title_sort	organocatalytic asymmetric n-sulfonyl amide c-n bond activation to access axially chiral biaryl amino acids
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0e8677445c7f41fa85cca6126fbd741e
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Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids

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