Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study

Abstract Background The prevalence of delirium, its associated factors, and its impact on long-term mortality among survivors of acute respiratory distress syndrome (ARDS) is unclear. Methods Since this was a population-based study, data were extracted from the National Health Insurance database in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tak Kyu Oh, Hye Youn Park, In-Ae Song
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Critical Care Delirium Mortality Respiratory distress syndrome Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/0e867f8deaf146779f66e961a6d28024
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e867f8deaf146779f66e961a6d28024
record_format	dspace
spelling	oai:doaj.org-article:0e867f8deaf146779f66e961a6d280242021-11-08T11:13:24ZFactors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study10.1186/s12890-021-01714-01471-2466https://doaj.org/article/0e867f8deaf146779f66e961a6d280242021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01714-0https://doaj.org/toc/1471-2466Abstract Background The prevalence of delirium, its associated factors, and its impact on long-term mortality among survivors of acute respiratory distress syndrome (ARDS) is unclear. Methods Since this was a population-based study, data were extracted from the National Health Insurance database in South Korea. All adults who were admitted to intensive care units with a diagnosis of ARDS between January 1, 2010, and December 31, 2019, and who survived for ≥ 60 days were included. The International Statistical Classification of Diseases and Related Health Problems, tenth revision code of delirium (F05) was used to extract delirium cases during hospitalization. Results A total of 6809 ARDS survivors were included in the analysis, and 319 patients (4.7%) were diagnosed with delirium during hospitalization. In the multivariable logistic regression analysis after covariate adjustment, male sex (odds ratio [OR] 1.60, 95% confidence interval [CI] 1.23, 2.08; P < 0.001), longer duration of hospitalization (OR 1.02, 95% CI 1.01, 1.03; P < 0.001), neuromuscular blockade use (OR 1.50, 95% CI 1.12, 2.01; P = 0.006), benzodiazepine (OR 1.55, 95% CI 1.13, 2.13; P = 0.007) and propofol (OR 1.48, 95% CI 1.01, 2.17; P = 0.046) continuous infusion, and concurrent depression (OR 1.31, 95% CI 1.01, 1.71; P = 0.044) were associated with a higher prevalence of delirium among ARDS survivors. In the multivariable Cox regression analysis after adjustment for covariates, the occurrence of delirium was not significantly associated with 1-year all-cause mortality, when compared to the other survivors who did not develop delirium (hazard ratio: 0.85, 95% CI 1.01, 1.71; P = 0.044). Conclusions In South Korea, 4.7% of ARDS survivors were diagnosed with delirium during hospitalization in South Korea. Some factors were potential risk factors for the development of delirium, but the occurrence of delirium might not affect 1-year all-cause mortality among ARDS survivors.Tak Kyu OhHye Youn ParkIn-Ae SongBMCarticleCritical CareDeliriumMortalityRespiratory distress syndromeDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Critical Care Delirium Mortality Respiratory distress syndrome Diseases of the respiratory system RC705-779
spellingShingle	Critical Care Delirium Mortality Respiratory distress syndrome Diseases of the respiratory system RC705-779 Tak Kyu Oh Hye Youn Park In-Ae Song Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
description	Abstract Background The prevalence of delirium, its associated factors, and its impact on long-term mortality among survivors of acute respiratory distress syndrome (ARDS) is unclear. Methods Since this was a population-based study, data were extracted from the National Health Insurance database in South Korea. All adults who were admitted to intensive care units with a diagnosis of ARDS between January 1, 2010, and December 31, 2019, and who survived for ≥ 60 days were included. The International Statistical Classification of Diseases and Related Health Problems, tenth revision code of delirium (F05) was used to extract delirium cases during hospitalization. Results A total of 6809 ARDS survivors were included in the analysis, and 319 patients (4.7%) were diagnosed with delirium during hospitalization. In the multivariable logistic regression analysis after covariate adjustment, male sex (odds ratio [OR] 1.60, 95% confidence interval [CI] 1.23, 2.08; P < 0.001), longer duration of hospitalization (OR 1.02, 95% CI 1.01, 1.03; P < 0.001), neuromuscular blockade use (OR 1.50, 95% CI 1.12, 2.01; P = 0.006), benzodiazepine (OR 1.55, 95% CI 1.13, 2.13; P = 0.007) and propofol (OR 1.48, 95% CI 1.01, 2.17; P = 0.046) continuous infusion, and concurrent depression (OR 1.31, 95% CI 1.01, 1.71; P = 0.044) were associated with a higher prevalence of delirium among ARDS survivors. In the multivariable Cox regression analysis after adjustment for covariates, the occurrence of delirium was not significantly associated with 1-year all-cause mortality, when compared to the other survivors who did not develop delirium (hazard ratio: 0.85, 95% CI 1.01, 1.71; P = 0.044). Conclusions In South Korea, 4.7% of ARDS survivors were diagnosed with delirium during hospitalization in South Korea. Some factors were potential risk factors for the development of delirium, but the occurrence of delirium might not affect 1-year all-cause mortality among ARDS survivors.
format	article
author	Tak Kyu Oh Hye Youn Park In-Ae Song
author_facet	Tak Kyu Oh Hye Youn Park In-Ae Song
author_sort	Tak Kyu Oh
title	Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
title_short	Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
title_full	Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
title_fullStr	Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
title_full_unstemmed	Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
title_sort	factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/0e867f8deaf146779f66e961a6d28024
work_keys_str_mv	AT takkyuoh factorsassociatedwithdeliriumamongsurvivorsofacuterespiratorydistresssyndromeanationwidecohortstudy AT hyeyounpark factorsassociatedwithdeliriumamongsurvivorsofacuterespiratorydistresssyndromeanationwidecohortstudy AT inaesong factorsassociatedwithdeliriumamongsurvivorsofacuterespiratorydistresssyndromeanationwidecohortstudy
_version_	1718442306781052928

Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study

Ejemplares similares