Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration

Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests...

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Autores principales: Laetitia Keller, Luc Pijnenburg, Ysia Idoux-Gillet, Fabien Bornert, Laila Benameur, Maryam Tabrizian, Pierrick Auvray, Philippe Rosset, Rosa María Gonzalo-Daganzo, Enrique Gómez Barrena, Luca Gentile, Nadia Benkirane-Jessel
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0e87c6a53bfe4743b575d595783d1218
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spelling oai:doaj.org-article:0e87c6a53bfe4743b575d595783d12182021-12-02T14:40:17ZPreclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration10.1038/s41467-019-10165-52041-1723https://doaj.org/article/0e87c6a53bfe4743b575d595783d12182019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10165-5https://doaj.org/toc/2041-1723Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.Laetitia KellerLuc PijnenburgYsia Idoux-GilletFabien BornertLaila BenameurMaryam TabrizianPierrick AuvrayPhilippe RossetRosa María Gonzalo-DaganzoEnrique Gómez BarrenaLuca GentileNadia Benkirane-JesselNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Laetitia Keller
Luc Pijnenburg
Ysia Idoux-Gillet
Fabien Bornert
Laila Benameur
Maryam Tabrizian
Pierrick Auvray
Philippe Rosset
Rosa María Gonzalo-Daganzo
Enrique Gómez Barrena
Luca Gentile
Nadia Benkirane-Jessel
Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
description Arthroplasty is the main clinical option for the treatment of osteoarticular lesions, but has limited efficacy. Here, the authors use a wound dressing with autologous mesenchymal stromal cells, functionalised for local BMP2 delivery, and show feasibility and safety in standardised preclinical tests in animal models, suggesting suitability for use in clinical trials.
format article
author Laetitia Keller
Luc Pijnenburg
Ysia Idoux-Gillet
Fabien Bornert
Laila Benameur
Maryam Tabrizian
Pierrick Auvray
Philippe Rosset
Rosa María Gonzalo-Daganzo
Enrique Gómez Barrena
Luca Gentile
Nadia Benkirane-Jessel
author_facet Laetitia Keller
Luc Pijnenburg
Ysia Idoux-Gillet
Fabien Bornert
Laila Benameur
Maryam Tabrizian
Pierrick Auvray
Philippe Rosset
Rosa María Gonzalo-Daganzo
Enrique Gómez Barrena
Luca Gentile
Nadia Benkirane-Jessel
author_sort Laetitia Keller
title Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
title_short Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
title_full Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
title_fullStr Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
title_full_unstemmed Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
title_sort preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0e87c6a53bfe4743b575d595783d1218
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