Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin

Effect of Differences in Metabolic Activity of Melanoma Models on Response to Lonidamine plus Doxorubicin

Abstract Lonidamine (LND), a metabolic modulator, sensitizes DB-1 human melanoma to doxorubicin (DOX) chemotherapy by acidifying and de-energizing the tumor. This report compares the effects of LND on two human melanoma lines, DB-1 and WM983B, which exhibit different metabolic properties. Using liqu...

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Autores principales: Kavindra Nath, Jeffrey Roman, David S. Nelson, Lili Guo, Seung-Cheol Lee, Stepan Orlovskiy, Kevin Muriuki, Daniel F. Heitjan, Stephen Pickup, Dennis B. Leeper, Ian A. Blair, Mary E. Putt, Jerry D. Glickson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Lonidamine (LND)
Growth Delay
Seahorse
Tumor Lactate Levels
Extracellular Acidification Rate (ECAR)
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/0e896a59367143cd9eaf61fe48cf3d20
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https://doaj.org/article/0e896a59367143cd9eaf61fe48cf3d20

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