Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing

Ruihua Cao, Yongyi Bai, Ruyi Xu, Ping Ye Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly lead...

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Autores principales:	Cao R, Bai Y, Xu R, Ye P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	resting heart rate N-terminal pro-brain natriuretic peptide Epidemiology cardiac function relationship Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0e8a9eb05a0f48b692294358df8d05bf
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spelling	oai:doaj.org-article:0e8a9eb05a0f48b692294358df8d05bf2021-12-02T00:32:52ZAssociation between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing1178-1998https://doaj.org/article/0e8a9eb05a0f48b692294358df8d05bf2014-12-01T00:00:00Zhttps://www.dovepress.com/association-between-resting-heart-rate-and-n-terminal-pro-brain-natriu-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ruihua Cao, Yongyi Bai, Ruyi Xu, Ping Ye Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly leads to heart failure. However, the relationship between resting heart rate and NT-proBNP is unclear.Objective: This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population.Methods: We evaluated the relativity between resting heart rate and plasma levels of NT-proBNP in 1,567 participants (mean age 61.0 years, range 21–96 years) from a community-based population in Beijing, People’s Republic of China.Results: In patients with high resting heart rate (≥75 beats/min), NT-proBNP was higher than in those having low resting heart rate (<75 beats/min). In multiple linear stepwise regression analysis, plasma NT-proBNP was associated with resting heart rate (partial correlation coefficient, 0.82; 95% confidence interval, 0.18–1.51; P=0.011). A subsequent subgroup analysis revealed that the association between resting heart rate and plasma NT-proBNP was strengthened in subjects over 60 years old (partial correlation coefficient 1.28; 95% confidence interval, 0.49–2.36; P=0.031); while the relativity between resting heart rate and plasma NT-proBNP was not emerged in the younger subgroup (<60 years old).Conclusions: Resting heart rate was associated with plasma NT-proBNP in the elderly, which indicated a relationship between resting heart rate and cardiac function damage. Keywords: resting heart rate, N-terminal pro-brain natriuretic peptide, epidemiology, cardiac function, relationshipCao RBai YXu RYe PDove Medical Pressarticleresting heart rateN-terminal pro-brain natriuretic peptideEpidemiologycardiac functionrelationshipGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 55-60 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	resting heart rate N-terminal pro-brain natriuretic peptide Epidemiology cardiac function relationship Geriatrics RC952-954.6
spellingShingle	resting heart rate N-terminal pro-brain natriuretic peptide Epidemiology cardiac function relationship Geriatrics RC952-954.6 Cao R Bai Y Xu R Ye P Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
description	Ruihua Cao, Yongyi Bai, Ruyi Xu, Ping Ye Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People’s Republic of China Background: N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly leads to heart failure. However, the relationship between resting heart rate and NT-proBNP is unclear.Objective: This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population.Methods: We evaluated the relativity between resting heart rate and plasma levels of NT-proBNP in 1,567 participants (mean age 61.0 years, range 21–96 years) from a community-based population in Beijing, People’s Republic of China.Results: In patients with high resting heart rate (≥75 beats/min), NT-proBNP was higher than in those having low resting heart rate (<75 beats/min). In multiple linear stepwise regression analysis, plasma NT-proBNP was associated with resting heart rate (partial correlation coefficient, 0.82; 95% confidence interval, 0.18–1.51; P=0.011). A subsequent subgroup analysis revealed that the association between resting heart rate and plasma NT-proBNP was strengthened in subjects over 60 years old (partial correlation coefficient 1.28; 95% confidence interval, 0.49–2.36; P=0.031); while the relativity between resting heart rate and plasma NT-proBNP was not emerged in the younger subgroup (<60 years old).Conclusions: Resting heart rate was associated with plasma NT-proBNP in the elderly, which indicated a relationship between resting heart rate and cardiac function damage. Keywords: resting heart rate, N-terminal pro-brain natriuretic peptide, epidemiology, cardiac function, relationship
format	article
author	Cao R Bai Y Xu R Ye P
author_facet	Cao R Bai Y Xu R Ye P
author_sort	Cao R
title	Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
title_short	Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
title_full	Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
title_fullStr	Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
title_full_unstemmed	Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing
title_sort	association between resting heart rate and n-terminal pro-brain natriuretic peptide in a community-based population study in beijing
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/0e8a9eb05a0f48b692294358df8d05bf
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Association between resting heart rate and N-terminal pro-brain natriuretic peptide in a community-based population study in Beijing

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