Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database

Takeshi Inoue,1 Hiromi Sano,2 Yoshitsugu Kojima,3 Sakiko Yamada,3 Osamu Shirakawa4 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan; 3Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan; 4Department of Neuro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Inoue T, Sano H, Kojima Y, Yamada S, Shirakawa O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bipolar disorders treatment patterns medication adherence oral antipsychotics mood stabilizers claims database. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0e8ad8b85ee2465092dc3d897673e536
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e8ad8b85ee2465092dc3d897673e536
record_format	dspace
spelling	oai:doaj.org-article:0e8ad8b85ee2465092dc3d897673e5362021-12-02T16:28:15ZReal-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database1178-2021https://doaj.org/article/0e8ad8b85ee2465092dc3d897673e5362021-03-01T00:00:00Zhttps://www.dovepress.com/real-world-treatment-patterns-and-adherence-to-oral-medication-among-p-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Takeshi Inoue,1 Hiromi Sano,2 Yoshitsugu Kojima,3 Sakiko Yamada,3 Osamu Shirakawa4 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan; 3Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan; 4Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, JapanCorrespondence: Sakiko YamadaMedical Affairs, Otsuka Pharmaceutical Co., Ltd., Shinagawa Grand Central Tower, 2-16-4 Konan, Minato-Ku, Tokyo, 108-8242, JapanTel +81 3 6717 1400Fax +81 3 6716 1398Email yamadasa@otsuka.jpPurpose: This study aimed to describe real-world treatment patterns and medication adherence among patients with bipolar disorder (BD) in Japan.Patients and Methods: Adult patients with a BD diagnosis were identified between July 2013 and February 2018, using an employment-based health insurance claims database from the JMDC Inc. Treatment patterns of target drugs (mood stabilizers, antipsychotics) and adherence (measured by the proportion of days covered [PDC]) were assessed during the first- through third-year follow-up. Adherence was also assessed for patient subgroups.Results: The analyzed population included 13,788 patients with BD. They were mostly prescribed sodium valproate, lithium, or aripiprazole (range: 21.1– 27.4%) across 3 years of follow-up, whereas lamotrigine was prescribed to 11.2– 12.8% of patients. Benzodiazepines (70– 87%) and antidepressants (52– 71%) were commonly prescribed during all three follow-up periods. The mean PDC among all patients with BD was 0.51 during the first and increased to 0.61 during the third year. The mean PDC was 0.42 (first year) in patients aged < 30 years and 0.49 in those aged 30– 40 years. The PDC was 0.44– 0.61 (depending on the drug class) in those who were prescribed a single-class target drug and 0.68– 0.83 in those prescribed two drug classes concomitantly.Conclusion: This study documented generally low medication adherence among patients with BD, and those at young age. These patients may require more attention.Keywords: bipolar disorders, treatment patterns, medication adherence, oral antipsychotics, mood stabilizers, claims databaseInoue TSano HKojima YYamada SShirakawa ODove Medical Pressarticlebipolar disorderstreatment patternsmedication adherenceoral antipsychoticsmood stabilizersclaims database.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 821-833 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorders treatment patterns medication adherence oral antipsychotics mood stabilizers claims database. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorders treatment patterns medication adherence oral antipsychotics mood stabilizers claims database. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Inoue T Sano H Kojima Y Yamada S Shirakawa O Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
description	Takeshi Inoue,1 Hiromi Sano,2 Yoshitsugu Kojima,3 Sakiko Yamada,3 Osamu Shirakawa4 1Department of Psychiatry, Tokyo Medical University, Tokyo, Japan; 2Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Osaka, Japan; 3Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan; 4Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, JapanCorrespondence: Sakiko YamadaMedical Affairs, Otsuka Pharmaceutical Co., Ltd., Shinagawa Grand Central Tower, 2-16-4 Konan, Minato-Ku, Tokyo, 108-8242, JapanTel +81 3 6717 1400Fax +81 3 6716 1398Email yamadasa@otsuka.jpPurpose: This study aimed to describe real-world treatment patterns and medication adherence among patients with bipolar disorder (BD) in Japan.Patients and Methods: Adult patients with a BD diagnosis were identified between July 2013 and February 2018, using an employment-based health insurance claims database from the JMDC Inc. Treatment patterns of target drugs (mood stabilizers, antipsychotics) and adherence (measured by the proportion of days covered [PDC]) were assessed during the first- through third-year follow-up. Adherence was also assessed for patient subgroups.Results: The analyzed population included 13,788 patients with BD. They were mostly prescribed sodium valproate, lithium, or aripiprazole (range: 21.1– 27.4%) across 3 years of follow-up, whereas lamotrigine was prescribed to 11.2– 12.8% of patients. Benzodiazepines (70– 87%) and antidepressants (52– 71%) were commonly prescribed during all three follow-up periods. The mean PDC among all patients with BD was 0.51 during the first and increased to 0.61 during the third year. The mean PDC was 0.42 (first year) in patients aged < 30 years and 0.49 in those aged 30– 40 years. The PDC was 0.44– 0.61 (depending on the drug class) in those who were prescribed a single-class target drug and 0.68– 0.83 in those prescribed two drug classes concomitantly.Conclusion: This study documented generally low medication adherence among patients with BD, and those at young age. These patients may require more attention.Keywords: bipolar disorders, treatment patterns, medication adherence, oral antipsychotics, mood stabilizers, claims database
format	article
author	Inoue T Sano H Kojima Y Yamada S Shirakawa O
author_facet	Inoue T Sano H Kojima Y Yamada S Shirakawa O
author_sort	Inoue T
title	Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
title_short	Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
title_full	Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
title_fullStr	Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
title_full_unstemmed	Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database
title_sort	real-world treatment patterns and adherence to oral medication among patients with bipolar disorders: a retrospective, observational study using a healthcare claims database
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0e8ad8b85ee2465092dc3d897673e536
work_keys_str_mv	AT inouet realworldtreatmentpatternsandadherencetooralmedicationamongpatientswithbipolardisordersaretrospectiveobservationalstudyusingahealthcareclaimsdatabase AT sanoh realworldtreatmentpatternsandadherencetooralmedicationamongpatientswithbipolardisordersaretrospectiveobservationalstudyusingahealthcareclaimsdatabase AT kojimay realworldtreatmentpatternsandadherencetooralmedicationamongpatientswithbipolardisordersaretrospectiveobservationalstudyusingahealthcareclaimsdatabase AT yamadas realworldtreatmentpatternsandadherencetooralmedicationamongpatientswithbipolardisordersaretrospectiveobservationalstudyusingahealthcareclaimsdatabase AT shirakawao realworldtreatmentpatternsandadherencetooralmedicationamongpatientswithbipolardisordersaretrospectiveobservationalstudyusingahealthcareclaimsdatabase
_version_	1718383914368630784

Real-World Treatment Patterns and Adherence to Oral Medication Among Patients with Bipolar Disorders: A Retrospective, Observational Study Using a Healthcare Claims Database

Ejemplares similares