Tunable drug loading and release from polypeptide multilayer nanofilms

Bingbing Jiang1, Bingyun Li1,2,31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA; 2WVNano Initiative, WV, USA; 3Department of Chemical Engineering, College of Engineering and Mineral Resources,...

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Autores principales:	Bingbing Jiang, Bingyun Li
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0e8d9c506e0246f6bafd764a2cb883e0
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spelling	oai:doaj.org-article:0e8d9c506e0246f6bafd764a2cb883e02021-12-02T00:24:26ZTunable drug loading and release from polypeptide multilayer nanofilms1176-91141178-2013https://doaj.org/article/0e8d9c506e0246f6bafd764a2cb883e02009-03-01T00:00:00Zhttp://www.dovepress.com/tunable-drug-loading-and-release-from-polypeptide-multilayer-nanofilms-a2933https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Bingbing Jiang1, Bingyun Li1,2,31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA; 2WVNano Initiative, WV, USA; 3Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, USA Abstract: Polypeptide multilayer nanofilms were prepared using electrostatic layer-by-layer self-assembly nanotechnology. Small charged drug molecules (eg, cefazolin, gentamicin, and methylene blue) were loaded in polypeptide multilayer nanofilms. Their loading and release were found to be pH-dependent and could also be controlled by changing the number of film layers and drug incubation time, and applying heat-treatment after film formation. Antibiotic-loaded polypeptide multilayer nanofilms showed controllable antibacterial properties against Staphylococcus aureus. The developed biodegradable polypeptide multilayer nanofilms are capable of loading both positively- and negatively-charged drug molecules and promise to serve as drug delivery systems on biomedical devices for preventing biomedical device-associated infection, which is a significant clinical complication for both civilian and military patients.Keywords: polypeptide, self-assembly, polyelectrolyte multilayer, nanofilm, charged molecule, tunable release Bingbing JiangBingyun LiDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 37-53 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Bingbing Jiang Bingyun Li Tunable drug loading and release from polypeptide multilayer nanofilms
description	Bingbing Jiang1, Bingyun Li1,2,31Biomaterials, Bioengineering and Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, WV, USA; 2WVNano Initiative, WV, USA; 3Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, USA Abstract: Polypeptide multilayer nanofilms were prepared using electrostatic layer-by-layer self-assembly nanotechnology. Small charged drug molecules (eg, cefazolin, gentamicin, and methylene blue) were loaded in polypeptide multilayer nanofilms. Their loading and release were found to be pH-dependent and could also be controlled by changing the number of film layers and drug incubation time, and applying heat-treatment after film formation. Antibiotic-loaded polypeptide multilayer nanofilms showed controllable antibacterial properties against Staphylococcus aureus. The developed biodegradable polypeptide multilayer nanofilms are capable of loading both positively- and negatively-charged drug molecules and promise to serve as drug delivery systems on biomedical devices for preventing biomedical device-associated infection, which is a significant clinical complication for both civilian and military patients.Keywords: polypeptide, self-assembly, polyelectrolyte multilayer, nanofilm, charged molecule, tunable release
format	article
author	Bingbing Jiang Bingyun Li
author_facet	Bingbing Jiang Bingyun Li
author_sort	Bingbing Jiang
title	Tunable drug loading and release from polypeptide multilayer nanofilms
title_short	Tunable drug loading and release from polypeptide multilayer nanofilms
title_full	Tunable drug loading and release from polypeptide multilayer nanofilms
title_fullStr	Tunable drug loading and release from polypeptide multilayer nanofilms
title_full_unstemmed	Tunable drug loading and release from polypeptide multilayer nanofilms
title_sort	tunable drug loading and release from polypeptide multilayer nanofilms
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/0e8d9c506e0246f6bafd764a2cb883e0
work_keys_str_mv	AT bingbingjiang tunabledrugloadingandreleasefrompolypeptidemultilayernanofilms AT bingyunli tunabledrugloadingandreleasefrompolypeptidemultilayernanofilms
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Tunable drug loading and release from polypeptide multilayer nanofilms

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