Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach

Abstract The study aims to examine the blood pressure (BP) trajectory during pregnancy and its association with pre-gravid BP level. In a pre-conception cohort study, newly-married women in Liuyang, China underwent pre-gravid measurements and were followed throughout the pregnancy. BP was measured a...

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Autores principales:	Minxue Shen, Hongzhuan Tan, Shujin Zhou, Graeme N. Smith, Mark C. Walker, Shi Wu Wen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e8fab5858aa4496850c14b282dbb0ce
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spelling	oai:doaj.org-article:0e8fab5858aa4496850c14b282dbb0ce2021-12-02T16:06:59ZTrajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach10.1038/s41598-017-06606-02045-2322https://doaj.org/article/0e8fab5858aa4496850c14b282dbb0ce2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06606-0https://doaj.org/toc/2045-2322Abstract The study aims to examine the blood pressure (BP) trajectory during pregnancy and its association with pre-gravid BP level. In a pre-conception cohort study, newly-married women in Liuyang, China underwent pre-gravid measurements and were followed throughout the pregnancy. BP was measured at pre-conception and again throughout pregnancy. The functional principal component analysis was used to examine the trajectory of BP changes during pregnancy. A total of 1282 women with a singleton pregnancy who had both pre-conception and gestational BP measurements performed were included in the final analysis. The results showed that BP decreased significantly in early pregnancy and increased thereafter, without BP drop around 20 weeks of gestation. Pre-gravid BP level was inversely associated with the BP drop in early pregnancy, such that women with higher pre-gravid BP had greater BP drop at the beginning, while women with the lowest pre-gravid BP level demonstrated no obvious BP drop throughout the entire pregnancy.Minxue ShenHongzhuan TanShujin ZhouGraeme N. SmithMark C. WalkerShi Wu WenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minxue Shen Hongzhuan Tan Shujin Zhou Graeme N. Smith Mark C. Walker Shi Wu Wen Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
description	Abstract The study aims to examine the blood pressure (BP) trajectory during pregnancy and its association with pre-gravid BP level. In a pre-conception cohort study, newly-married women in Liuyang, China underwent pre-gravid measurements and were followed throughout the pregnancy. BP was measured at pre-conception and again throughout pregnancy. The functional principal component analysis was used to examine the trajectory of BP changes during pregnancy. A total of 1282 women with a singleton pregnancy who had both pre-conception and gestational BP measurements performed were included in the final analysis. The results showed that BP decreased significantly in early pregnancy and increased thereafter, without BP drop around 20 weeks of gestation. Pre-gravid BP level was inversely associated with the BP drop in early pregnancy, such that women with higher pre-gravid BP had greater BP drop at the beginning, while women with the lowest pre-gravid BP level demonstrated no obvious BP drop throughout the entire pregnancy.
format	article
author	Minxue Shen Hongzhuan Tan Shujin Zhou Graeme N. Smith Mark C. Walker Shi Wu Wen
author_facet	Minxue Shen Hongzhuan Tan Shujin Zhou Graeme N. Smith Mark C. Walker Shi Wu Wen
author_sort	Minxue Shen
title	Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
title_short	Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
title_full	Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
title_fullStr	Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
title_full_unstemmed	Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
title_sort	trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e8fab5858aa4496850c14b282dbb0ce
work_keys_str_mv	AT minxueshen trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach AT hongzhuantan trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach AT shujinzhou trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach AT graemensmith trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach AT markcwalker trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach AT shiwuwen trajectoryofbloodpressurechangeduringpregnancyandtheroleofpregravidbloodpressureafunctionaldataanalysisapproach
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Trajectory of blood pressure change during pregnancy and the role of pre-gravid blood pressure: a functional data analysis approach

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