RHO GTPase-Related Long Noncoding RNAs in Human Cancers

RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to...

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Autores principales:	Mahsa Saliani, Amin Mirzaiebadizi, Niloufar Mosaddeghzadeh, Mohammad Reza Ahmadian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	carcinogenesis lncRNAs miRNAs RHO GTPases signal transduction sponge effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/0e9046a061174c0aa96307e152689a2a
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spelling	oai:doaj.org-article:0e9046a061174c0aa96307e152689a2a2021-11-11T15:29:44ZRHO GTPase-Related Long Noncoding RNAs in Human Cancers10.3390/cancers132153862072-6694https://doaj.org/article/0e9046a061174c0aa96307e152689a2a2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5386https://doaj.org/toc/2072-6694RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis.Mahsa SalianiAmin MirzaiebadiziNiloufar MosaddeghzadehMohammad Reza AhmadianMDPI AGarticlecarcinogenesislncRNAsmiRNAsRHO GTPasessignal transductionsponge effectNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5386, p 5386 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carcinogenesis lncRNAs miRNAs RHO GTPases signal transduction sponge effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	carcinogenesis lncRNAs miRNAs RHO GTPases signal transduction sponge effect Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian RHO GTPase-Related Long Noncoding RNAs in Human Cancers
description	RHO GTPases are critical signal transducers that regulate cell adhesion, polarity, and migration through multiple signaling pathways. While all these cellular processes are crucial for the maintenance of normal cell homeostasis, disturbances in RHO GTPase-associated signaling pathways contribute to different human diseases, including many malignancies. Several members of the RHO GTPase family are frequently upregulated in human tumors. Abnormal gene regulation confirms the pivotal role of lncRNAs as critical gene regulators, and thus, they could potentially act as oncogenes or tumor suppressors. lncRNAs most likely act as sponges for miRNAs, which are known to be dysregulated in various cancers. In this regard, the significant role of miRNAs targeting RHO GTPases supports the view that the aberrant expression of lncRNAs may reciprocally change the intensity of RHO GTPase-associated signaling pathways. In this review article, we summarize recent advances in lncRNA research, with a specific focus on their sponge effects on RHO GTPase-targeting miRNAs to crucially mediate gene expression in different cancer cell types and tissues. We will focus in particular on five members of the RHO GTPase family, including RHOA, RHOB, RHOC, RAC1, and CDC42, to illustrate the role of lncRNAs in cancer progression. A deeper understanding of the widespread dysregulation of lncRNAs is of fundamental importance for confirmation of their contribution to RHO GTPase-dependent carcinogenesis.
format	article
author	Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian
author_facet	Mahsa Saliani Amin Mirzaiebadizi Niloufar Mosaddeghzadeh Mohammad Reza Ahmadian
author_sort	Mahsa Saliani
title	RHO GTPase-Related Long Noncoding RNAs in Human Cancers
title_short	RHO GTPase-Related Long Noncoding RNAs in Human Cancers
title_full	RHO GTPase-Related Long Noncoding RNAs in Human Cancers
title_fullStr	RHO GTPase-Related Long Noncoding RNAs in Human Cancers
title_full_unstemmed	RHO GTPase-Related Long Noncoding RNAs in Human Cancers
title_sort	rho gtpase-related long noncoding rnas in human cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0e9046a061174c0aa96307e152689a2a
work_keys_str_mv	AT mahsasaliani rhogtpaserelatedlongnoncodingrnasinhumancancers AT aminmirzaiebadizi rhogtpaserelatedlongnoncodingrnasinhumancancers AT niloufarmosaddeghzadeh rhogtpaserelatedlongnoncodingrnasinhumancancers AT mohammadrezaahmadian rhogtpaserelatedlongnoncodingrnasinhumancancers
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RHO GTPase-Related Long Noncoding RNAs in Human Cancers

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