Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy

Aim. To investigate the level of hydrogen sulfide in patients with type 2 diabetes depending on the presence of diabetic nephropathy. Material and Methods. The investigation included 70 patients with T2D (40 men and 30 women). Besides standard laboratory examination, additional sample of blood fo...

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Autores principales:	D.Yu. Kutsyk, Ye.Ya. Sklyarov
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2017
Materias:	hydrogen sulfide, diabetic nephropathy, microalbuminuria Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0e914f6349eb4e8ab262b519b58f138a
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spelling	oai:doaj.org-article:0e914f6349eb4e8ab262b519b58f138a2021-11-10T19:50:04ZLevel of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy1029-42442415-330310.25040/aml2017.04.012https://doaj.org/article/0e914f6349eb4e8ab262b519b58f138a2017-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/134https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To investigate the level of hydrogen sulfide in patients with type 2 diabetes depending on the presence of diabetic nephropathy. Material and Methods. The investigation included 70 patients with T2D (40 men and 30 women). Besides standard laboratory examination, additional sample of blood for hydrogen sulfide was taken and a 24-hour urine sample for microalbuminuria was collected. All patients were divided in two groups: patients without DN and with DN. Patients underwent antidiabetic treatment with metformin. Independent Student t-test was used to compare the differences between the groups, and Pearson correlation coefficient (r) was calculated. Results and Discussion. It was revealed that hydrogen sulfide level in patients with diabetic nephropathy is significantly decreased and shows negative correlates with indicators of diabetic nephropathy - microalbumin and glomerular filtration rate. Conclusions. Level of hydrogen sulfide is decreased in patients with diabetic nephropathy and can serve as its early indicator.D.Yu. KutsykYe.Ya. SklyarovDanylo Halytsky Lviv National Medical Universityarticlehydrogen sulfide, diabetic nephropathy, microalbuminuriaMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 23, Iss 4, Pp 12-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	hydrogen sulfide, diabetic nephropathy, microalbuminuria Medicine (General) R5-920
spellingShingle	hydrogen sulfide, diabetic nephropathy, microalbuminuria Medicine (General) R5-920 D.Yu. Kutsyk Ye.Ya. Sklyarov Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
description	Aim. To investigate the level of hydrogen sulfide in patients with type 2 diabetes depending on the presence of diabetic nephropathy. Material and Methods. The investigation included 70 patients with T2D (40 men and 30 women). Besides standard laboratory examination, additional sample of blood for hydrogen sulfide was taken and a 24-hour urine sample for microalbuminuria was collected. All patients were divided in two groups: patients without DN and with DN. Patients underwent antidiabetic treatment with metformin. Independent Student t-test was used to compare the differences between the groups, and Pearson correlation coefficient (r) was calculated. Results and Discussion. It was revealed that hydrogen sulfide level in patients with diabetic nephropathy is significantly decreased and shows negative correlates with indicators of diabetic nephropathy - microalbumin and glomerular filtration rate. Conclusions. Level of hydrogen sulfide is decreased in patients with diabetic nephropathy and can serve as its early indicator.
format	article
author	D.Yu. Kutsyk Ye.Ya. Sklyarov
author_facet	D.Yu. Kutsyk Ye.Ya. Sklyarov
author_sort	D.Yu. Kutsyk
title	Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
title_short	Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
title_full	Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
title_fullStr	Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
title_full_unstemmed	Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
title_sort	level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2017
url	https://doaj.org/article/0e914f6349eb4e8ab262b519b58f138a
work_keys_str_mv	AT dyukutsyk levelofhydrogensulfideinpatientswithtype2diabetesmellitusdependingonthepresenceofdiabeticnephropathy AT yeyasklyarov levelofhydrogensulfideinpatientswithtype2diabetesmellitusdependingonthepresenceofdiabeticnephropathy
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Level of hydrogen sulfide in patients with type 2 diabetes mellitus depending on the presence of diabetic nephropathy

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