Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.

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Detalles Bibliográficos
Autores principales:	Andrew S. Moore, Yvette C. Wong, Cory L. Simpson, Erika L. F. Holzbaur
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e9389272a8b4fed82dd37cc0126d9f8
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spelling	oai:doaj.org-article:0e9389272a8b4fed82dd37cc0126d9f82021-12-02T14:38:55ZDynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks10.1038/ncomms128862041-1723https://doaj.org/article/0e9389272a8b4fed82dd37cc0126d9f82016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12886https://doaj.org/toc/2041-1723Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.Andrew S. MooreYvette C. WongCory L. SimpsonErika L. F. HolzbaurNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew S. Moore Yvette C. Wong Cory L. Simpson Erika L. F. Holzbaur Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
description	Mitochondria are dynamic organelles that can undergo fission and fusion. Here the authors identify a novel pathway in which actin dynamically assembles in an Arp2/3- and formin-dependent manner around a subset of cellular mitochondria, promoting localized Drp1-dependent fission and impeding fusion.
format	article
author	Andrew S. Moore Yvette C. Wong Cory L. Simpson Erika L. F. Holzbaur
author_facet	Andrew S. Moore Yvette C. Wong Cory L. Simpson Erika L. F. Holzbaur
author_sort	Andrew S. Moore
title	Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
title_short	Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
title_full	Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
title_fullStr	Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
title_full_unstemmed	Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
title_sort	dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0e9389272a8b4fed82dd37cc0126d9f8
work_keys_str_mv	AT andrewsmoore dynamicactincyclingthroughmitochondrialsubpopulationslocallyregulatesthefissionfusionbalancewithinmitochondrialnetworks AT yvettecwong dynamicactincyclingthroughmitochondrialsubpopulationslocallyregulatesthefissionfusionbalancewithinmitochondrialnetworks AT corylsimpson dynamicactincyclingthroughmitochondrialsubpopulationslocallyregulatesthefissionfusionbalancewithinmitochondrialnetworks AT erikalfholzbaur dynamicactincyclingthroughmitochondrialsubpopulationslocallyregulatesthefissionfusionbalancewithinmitochondrialnetworks
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Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

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