Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodil...

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Autores principales:	Cheng Jiang, Ying Fu, Guozhen Liu, Bowen Shu, Jason Davis, George K. Tofaris
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Multiplexed profiling Extracellular vesicles Exosomes Liquid biopsy Point-of-care Biomarker Technology T
Acceso en línea:	https://doaj.org/article/0e94b871b3eb4599b6e367ae0c7d8eb0
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id	oai:doaj.org-article:0e94b871b3eb4599b6e367ae0c7d8eb0
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spelling	oai:doaj.org-article:0e94b871b3eb4599b6e367ae0c7d8eb02021-12-05T12:04:53ZMultiplexed Profiling of Extracellular Vesicles for Biomarker Development10.1007/s40820-021-00753-w2311-67062150-5551https://doaj.org/article/0e94b871b3eb4599b6e367ae0c7d8eb02021-12-01T00:00:00Zhttps://doi.org/10.1007/s40820-021-00753-whttps://doaj.org/toc/2311-6706https://doaj.org/toc/2150-5551Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.Cheng JiangYing FuGuozhen LiuBowen ShuJason DavisGeorge K. TofarisSpringerOpenarticleMultiplexed profilingExtracellular vesiclesExosomesLiquid biopsyPoint-of-careBiomarkerTechnologyTENNano-Micro Letters, Vol 14, Iss 1, Pp 1-36 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiplexed profiling Extracellular vesicles Exosomes Liquid biopsy Point-of-care Biomarker Technology T
spellingShingle	Multiplexed profiling Extracellular vesicles Exosomes Liquid biopsy Point-of-care Biomarker Technology T Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K. Tofaris Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
description	Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer and neurodegeneration. EVs are detected in all bodily fluids, and their protein and nucleic acid content offers a means of assessing the status of the cells from which they originated. As such, they provide opportunities in biomarker discovery for diagnosis, prognosis or the stratification of diseases as well as an objective monitoring of therapies. The simultaneous assaying of multiple EV-derived markers will be required for an impactful practical application, and multiplexing platforms have evolved with the potential to achieve this. Herein, we provide a comprehensive overview of the currently available multiplexing platforms for EV analysis, with a primary focus on miniaturized and integrated devices that offer potential step changes in analytical power, throughput and consistency.
format	article
author	Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K. Tofaris
author_facet	Cheng Jiang Ying Fu Guozhen Liu Bowen Shu Jason Davis George K. Tofaris
author_sort	Cheng Jiang
title	Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
title_short	Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
title_full	Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
title_fullStr	Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
title_full_unstemmed	Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
title_sort	multiplexed profiling of extracellular vesicles for biomarker development
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/0e94b871b3eb4599b6e367ae0c7d8eb0
work_keys_str_mv	AT chengjiang multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment AT yingfu multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment AT guozhenliu multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment AT bowenshu multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment AT jasondavis multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment AT georgektofaris multiplexedprofilingofextracellularvesiclesforbiomarkerdevelopment
_version_	1718372237030981632

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development

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