EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer

Although T-cell infiltration is correlated with EMT-related gene expression in urothelial cancer specimens, here, the authors report EMT-related signatures in urothelial cancer arise mainly from stromal cells. Increased EMT-related gene expression in T-cell infiltrated tumors is associated with an a...

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Autores principales:	Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0e94d49acf9b403fa3f22b69087eb769
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:0e94d49acf9b403fa3f22b69087eb7692021-12-02T15:34:37ZEMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer10.1038/s41467-018-05992-x2041-1723https://doaj.org/article/0e94d49acf9b403fa3f22b69087eb7692018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05992-xhttps://doaj.org/toc/2041-1723Although T-cell infiltration is correlated with EMT-related gene expression in urothelial cancer specimens, here, the authors report EMT-related signatures in urothelial cancer arise mainly from stromal cells. Increased EMT-related gene expression in T-cell infiltrated tumors is associated with an attenuated response to immune checkpoint blockade, providing a rationale for therapeutic co-targeting PD-1 and stromal elements.Li WangAbdel SaciPeter M. SzaboScott D. ChasalowMireia Castillo-MartinJosep Domingo-DomenechArlene Siefker-RadtkePadmanee SharmaJohn P. SfakianosYixuan GongAna Dominguez-AndresWilliam K. OhDavid MulhollandAlex AzrilevichLiangyuan HuCarlos Cordon-CardoHélène SalmonNina BhardwajJun ZhuMatthew D. GalskyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Wang Abdel Saci Peter M. Szabo Scott D. Chasalow Mireia Castillo-Martin Josep Domingo-Domenech Arlene Siefker-Radtke Padmanee Sharma John P. Sfakianos Yixuan Gong Ana Dominguez-Andres William K. Oh David Mulholland Alex Azrilevich Liangyuan Hu Carlos Cordon-Cardo Hélène Salmon Nina Bhardwaj Jun Zhu Matthew D. Galsky EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
description	Although T-cell infiltration is correlated with EMT-related gene expression in urothelial cancer specimens, here, the authors report EMT-related signatures in urothelial cancer arise mainly from stromal cells. Increased EMT-related gene expression in T-cell infiltrated tumors is associated with an attenuated response to immune checkpoint blockade, providing a rationale for therapeutic co-targeting PD-1 and stromal elements.
format	article
author	Li Wang Abdel Saci Peter M. Szabo Scott D. Chasalow Mireia Castillo-Martin Josep Domingo-Domenech Arlene Siefker-Radtke Padmanee Sharma John P. Sfakianos Yixuan Gong Ana Dominguez-Andres William K. Oh David Mulholland Alex Azrilevich Liangyuan Hu Carlos Cordon-Cardo Hélène Salmon Nina Bhardwaj Jun Zhu Matthew D. Galsky
author_facet	Li Wang Abdel Saci Peter M. Szabo Scott D. Chasalow Mireia Castillo-Martin Josep Domingo-Domenech Arlene Siefker-Radtke Padmanee Sharma John P. Sfakianos Yixuan Gong Ana Dominguez-Andres William K. Oh David Mulholland Alex Azrilevich Liangyuan Hu Carlos Cordon-Cardo Hélène Salmon Nina Bhardwaj Jun Zhu Matthew D. Galsky
author_sort	Li Wang
title	EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
title_short	EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
title_full	EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
title_fullStr	EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
title_full_unstemmed	EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
title_sort	emt- and stroma-related gene expression and resistance to pd-1 blockade in urothelial cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0e94d49acf9b403fa3f22b69087eb769
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EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer

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