Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
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Nature Portfolio
2017
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oai:doaj.org-article:0e94ef7a2a0944adb3f0ebb1ddc02cb82021-12-02T14:40:37ZDendrogenin A drives LXR to trigger lethal autophagy in cancers10.1038/s41467-017-01948-92041-1723https://doaj.org/article/0e94ef7a2a0944adb3f0ebb1ddc02cb82017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01948-9https://doaj.org/toc/2041-1723Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.Gregory SegalaMarion DavidPhilippe de MedinaMathias C. PoirotNizar SerhanFrançois VergezAurelie MougelEstelle SalandKevin CarayonJulie LeignadierNicolas CaronMaud VoisinJulia CherierLaetitia LigatFrederic LopezEmmanuel NoguerArnaud RivesBruno PayréTalal al SaatiAntonin LamaziereGaëtan DespresJean-Marc LobaccaroSilvere BaronCecile DemurFabienne de ToniClément LarrueHelena BoutzenFabienne ThomasJean-Emmanuel SarryMarie TosoliniDidier PicardMichel RecordChristian RécherMarc PoirotSandrine Silvente-PoirotNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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Science Q Gregory Segala Marion David Philippe de Medina Mathias C. Poirot Nizar Serhan François Vergez Aurelie Mougel Estelle Saland Kevin Carayon Julie Leignadier Nicolas Caron Maud Voisin Julia Cherier Laetitia Ligat Frederic Lopez Emmanuel Noguer Arnaud Rives Bruno Payré Talal al Saati Antonin Lamaziere Gaëtan Despres Jean-Marc Lobaccaro Silvere Baron Cecile Demur Fabienne de Toni Clément Larrue Helena Boutzen Fabienne Thomas Jean-Emmanuel Sarry Marie Tosolini Didier Picard Michel Record Christian Récher Marc Poirot Sandrine Silvente-Poirot Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| description |
Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia. |
| format |
article |
| author |
Gregory Segala Marion David Philippe de Medina Mathias C. Poirot Nizar Serhan François Vergez Aurelie Mougel Estelle Saland Kevin Carayon Julie Leignadier Nicolas Caron Maud Voisin Julia Cherier Laetitia Ligat Frederic Lopez Emmanuel Noguer Arnaud Rives Bruno Payré Talal al Saati Antonin Lamaziere Gaëtan Despres Jean-Marc Lobaccaro Silvere Baron Cecile Demur Fabienne de Toni Clément Larrue Helena Boutzen Fabienne Thomas Jean-Emmanuel Sarry Marie Tosolini Didier Picard Michel Record Christian Récher Marc Poirot Sandrine Silvente-Poirot |
| author_facet |
Gregory Segala Marion David Philippe de Medina Mathias C. Poirot Nizar Serhan François Vergez Aurelie Mougel Estelle Saland Kevin Carayon Julie Leignadier Nicolas Caron Maud Voisin Julia Cherier Laetitia Ligat Frederic Lopez Emmanuel Noguer Arnaud Rives Bruno Payré Talal al Saati Antonin Lamaziere Gaëtan Despres Jean-Marc Lobaccaro Silvere Baron Cecile Demur Fabienne de Toni Clément Larrue Helena Boutzen Fabienne Thomas Jean-Emmanuel Sarry Marie Tosolini Didier Picard Michel Record Christian Récher Marc Poirot Sandrine Silvente-Poirot |
| author_sort |
Gregory Segala |
| title |
Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| title_short |
Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| title_full |
Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| title_fullStr |
Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| title_full_unstemmed |
Dendrogenin A drives LXR to trigger lethal autophagy in cancers |
| title_sort |
dendrogenin a drives lxr to trigger lethal autophagy in cancers |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0e94ef7a2a0944adb3f0ebb1ddc02cb8 |
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