Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome

Abstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using un...

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Autores principales:	Hsiang-Yu Tang, Daniel Tsun-yee Chiu, Jui-Fen Lin, Cheng-Yu Huang, Kuo-Hsuan Chang, Rong-Kuo Lyu, Long-Sun Ro, Hung-Chou Kuo, Mei-Ling Cheng, Chiung-Mei Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e95220375774a9a99ff92ec8703f65d
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spelling	oai:doaj.org-article:0e95220375774a9a99ff92ec8703f65d2021-12-02T15:05:36ZDisturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome10.1038/s41598-017-08338-72045-2322https://doaj.org/article/0e95220375774a9a99ff92ec8703f65d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08338-7https://doaj.org/toc/2045-2322Abstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using untargeted and targeted metabolomics analysis. The untargeted analysis showed that levels of a set of plasma lipid metabolites were significantly decreased in GBS patients compared to the controls. Furthermore, the targeted analysis demonstrated that levels of 41 metabolites in GBS patients were significantly changed compared to either the controls or MS patients. A further metabolic analysis showed that 12 of 41 metabolites were significantly lower in classical GBS patients compared to Miller-Fisher syndrome. Among them, each of PCae C34:0, PCae C42:2, PCae C42:3, and SM C24:0 was inversely correlated with Hughes functional grading scale of GBS patients at both nadir and discharge. Receiver operating characteristic curve analysis of combination of three metabolites (PCaa C42:2, PCae C36:0 and SM C24:0) showed a good discrimination between the GBS and the controls (area under curve = 0.86). This study has demonstrated disruption of lipid metabolites in GBS may be potential biomarkers to indicate disease severity and prognosis of GBS.Hsiang-Yu TangDaniel Tsun-yee ChiuJui-Fen LinCheng-Yu HuangKuo-Hsuan ChangRong-Kuo LyuLong-Sun RoHung-Chou KuoMei-Ling ChengChiung-Mei ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
description	Abstract Guillain-Barre Syndrome (GBS) is an inflammatory disease of the peripheral nervous system. Given that plasma metabolic profiles in GBS patients have never been explored, plasma samples of 38 GBS patients, 22 multiple sclerosis (MS) patients, and 40 healthy controls were analyzed by using untargeted and targeted metabolomics analysis. The untargeted analysis showed that levels of a set of plasma lipid metabolites were significantly decreased in GBS patients compared to the controls. Furthermore, the targeted analysis demonstrated that levels of 41 metabolites in GBS patients were significantly changed compared to either the controls or MS patients. A further metabolic analysis showed that 12 of 41 metabolites were significantly lower in classical GBS patients compared to Miller-Fisher syndrome. Among them, each of PCae C34:0, PCae C42:2, PCae C42:3, and SM C24:0 was inversely correlated with Hughes functional grading scale of GBS patients at both nadir and discharge. Receiver operating characteristic curve analysis of combination of three metabolites (PCaa C42:2, PCae C36:0 and SM C24:0) showed a good discrimination between the GBS and the controls (area under curve = 0.86). This study has demonstrated disruption of lipid metabolites in GBS may be potential biomarkers to indicate disease severity and prognosis of GBS.
format	article
author	Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen
author_facet	Hsiang-Yu Tang Daniel Tsun-yee Chiu Jui-Fen Lin Cheng-Yu Huang Kuo-Hsuan Chang Rong-Kuo Lyu Long-Sun Ro Hung-Chou Kuo Mei-Ling Cheng Chiung-Mei Chen
author_sort	Hsiang-Yu Tang
title	Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
title_short	Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
title_full	Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
title_fullStr	Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
title_full_unstemmed	Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome
title_sort	disturbance of plasma lipid metabolic profile in guillain-barre syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e95220375774a9a99ff92ec8703f65d
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Disturbance of Plasma Lipid Metabolic Profile in Guillain-Barre Syndrome

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