A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones

Abstract Synaptic vesicles (SVs) fuse with the presynaptic membrane (PM) at specialized regions called active zones for synaptic transmission. SVs are associated with dense aggregates of macromolecules called active zone material (AZM) that has been thought to be involved in SV release. However, its...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jae Hoon Jung, Sebatian Doniach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0e96c4a5a3714f3880e6516a4dd37ee0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0e96c4a5a3714f3880e6516a4dd37ee0
record_format	dspace
spelling	oai:doaj.org-article:0e96c4a5a3714f3880e6516a4dd37ee02021-12-02T12:31:59ZA stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones10.1038/s41598-017-00360-z2045-2322https://doaj.org/article/0e96c4a5a3714f3880e6516a4dd37ee02017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00360-zhttps://doaj.org/toc/2045-2322Abstract Synaptic vesicles (SVs) fuse with the presynaptic membrane (PM) at specialized regions called active zones for synaptic transmission. SVs are associated with dense aggregates of macromolecules called active zone material (AZM) that has been thought to be involved in SV release. However, its role has recently begun to be elucidated. Several morphological studies proposed distinctively different AZM mediated SV docking and priming models: sequential and concurrent SV docking/priming. To explore ways to reconcile the contradictory models we develop a stochastic AZM mediated SV docking and priming model. We assume that the position of each connection site of the AZM macromolecules on their SV, directly linking the SV with the PM, varies by random shortening and lengthening of the macromolecules at resting active zones. We also perform computer simulations of SVs near the PM at resting active zones, and the results show that the distribution of the AZM connection sites can significantly affect the SV’s docking efficiency and distribution of its contact area with the PM, thus priming and that the area correlates with the shape of the SVs providing a way to account for seemingly irreconcilable observations reported about the spatial relationship of SVs with the PM at active zones.Jae Hoon JungSebatian DoniachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Hoon Jung Sebatian Doniach A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
description	Abstract Synaptic vesicles (SVs) fuse with the presynaptic membrane (PM) at specialized regions called active zones for synaptic transmission. SVs are associated with dense aggregates of macromolecules called active zone material (AZM) that has been thought to be involved in SV release. However, its role has recently begun to be elucidated. Several morphological studies proposed distinctively different AZM mediated SV docking and priming models: sequential and concurrent SV docking/priming. To explore ways to reconcile the contradictory models we develop a stochastic AZM mediated SV docking and priming model. We assume that the position of each connection site of the AZM macromolecules on their SV, directly linking the SV with the PM, varies by random shortening and lengthening of the macromolecules at resting active zones. We also perform computer simulations of SVs near the PM at resting active zones, and the results show that the distribution of the AZM connection sites can significantly affect the SV’s docking efficiency and distribution of its contact area with the PM, thus priming and that the area correlates with the shape of the SVs providing a way to account for seemingly irreconcilable observations reported about the spatial relationship of SVs with the PM at active zones.
format	article
author	Jae Hoon Jung Sebatian Doniach
author_facet	Jae Hoon Jung Sebatian Doniach
author_sort	Jae Hoon Jung
title	A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
title_short	A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
title_full	A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
title_fullStr	A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
title_full_unstemmed	A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
title_sort	stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0e96c4a5a3714f3880e6516a4dd37ee0
work_keys_str_mv	AT jaehoonjung astochasticmodelofactivezonematerialmediatedsynapticvesicledockingandprimingatrestingactivezones AT sebatiandoniach astochasticmodelofactivezonematerialmediatedsynapticvesicledockingandprimingatrestingactivezones AT jaehoonjung stochasticmodelofactivezonematerialmediatedsynapticvesicledockingandprimingatrestingactivezones AT sebatiandoniach stochasticmodelofactivezonematerialmediatedsynapticvesicledockingandprimingatrestingactivezones
_version_	1718394199992172544

A stochastic model of active zone material mediated synaptic vesicle docking and priming at resting active zones

Ejemplares similares