Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0e98e6e6394d47f4b1f34dfd27a30caf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0e98e6e6394d47f4b1f34dfd27a30caf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0e98e6e6394d47f4b1f34dfd27a30caf2021-12-02T18:34:07ZWithin-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation10.1038/s41467-020-17327-w2041-1723https://doaj.org/article/0e98e6e6394d47f4b1f34dfd27a30caf2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17327-whttps://doaj.org/toc/2041-1723Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous recombination.Chrispin ChaguzaMadikay SenghoreEbrima BojangRebecca A. GladstoneStephanie W. LoPeggy-Estelle TientcheuRowan E. BancroftArchibald WorwuiEbenezer Foster-NyarkoFatima CeesayCatherine OkoiLesley McGeeKeith P. KlugmanRobert F. BreimanMichael R. BarerRichard A. AdegbolaMartin AntonioStephen D. BentleyBrenda A. Kwambana-AdamsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chrispin Chaguza Madikay Senghore Ebrima Bojang Rebecca A. Gladstone Stephanie W. Lo Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| description |
Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous recombination. |
| format |
article |
| author |
Chrispin Chaguza Madikay Senghore Ebrima Bojang Rebecca A. Gladstone Stephanie W. Lo Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams |
| author_facet |
Chrispin Chaguza Madikay Senghore Ebrima Bojang Rebecca A. Gladstone Stephanie W. Lo Peggy-Estelle Tientcheu Rowan E. Bancroft Archibald Worwui Ebenezer Foster-Nyarko Fatima Ceesay Catherine Okoi Lesley McGee Keith P. Klugman Robert F. Breiman Michael R. Barer Richard A. Adegbola Martin Antonio Stephen D. Bentley Brenda A. Kwambana-Adams |
| author_sort |
Chrispin Chaguza |
| title |
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| title_short |
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| title_full |
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| title_fullStr |
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| title_full_unstemmed |
Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| title_sort |
within-host microevolution of streptococcus pneumoniae is rapid and adaptive during natural colonisation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/0e98e6e6394d47f4b1f34dfd27a30caf |
| work_keys_str_mv |
AT chrispinchaguza withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT madikaysenghore withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT ebrimabojang withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT rebeccaagladstone withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT stephaniewlo withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT peggyestelletientcheu withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT rowanebancroft withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT archibaldworwui withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT ebenezerfosternyarko withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT fatimaceesay withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT catherineokoi withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT lesleymcgee withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT keithpklugman withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT robertfbreiman withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT michaelrbarer withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT richardaadegbola withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT martinantonio withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT stephendbentley withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation AT brendaakwambanaadams withinhostmicroevolutionofstreptococcuspneumoniaeisrapidandadaptiveduringnaturalcolonisation |
| _version_ |
1718377902350794752 |