Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy

Arief Kartasasmita, Wendy P Muntur, Sutarya Enus, Erwin Iskandar Faculty of Medicine, Universitas Padjadjaran, Cicendo National Eye Hospital, Bandung, Indonesia Purpose: To compare the effectiveness of quadruple-drug therapy consisting of cotrimoxazole (trimethopin and sulfamethoxazole), clindamyc...

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Autores principales:	Kartasasmita A, Muntur WP, Enus S, Iskandar E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	toxoplasma chorioretinitis quadruple drug therapy triple-drug therapy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0e9fe9fe44e6402794f2b147b4524383
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spelling	oai:doaj.org-article:0e9fe9fe44e6402794f2b147b45243832021-12-02T00:15:13ZRapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy1177-5483https://doaj.org/article/0e9fe9fe44e6402794f2b147b45243832017-12-01T00:00:00Zhttps://www.dovepress.com/rapid-resolution-of-toxoplasma-chorioretinitis-treatment-using-quadrup-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Arief Kartasasmita, Wendy P Muntur, Sutarya Enus, Erwin Iskandar Faculty of Medicine, Universitas Padjadjaran, Cicendo National Eye Hospital, Bandung, Indonesia Purpose: To compare the effectiveness of quadruple-drug therapy consisting of cotrimoxazole (trimethopin and sulfamethoxazole), clindamycin antibiotics, and oral corticosteroid versus triple therapy consisting of pyrimetamine, sulphadiazine, and oral corticosteroid in the resolution of toxoplasmic chorioretinitis. Methods: This was a double-blind randomized controlled trial with repeated measures using parallel design to compare the effectiveness of quadruple-drug therapy and triple-drug therapy in patients with toxoplasmic chorioretinitis. The measurement of lesion was done using automated computer software, calculating the average of lesion size from three fundus photographs taken from the baseline and at each follow-up visit. The analytical statistics were obtained using Mann–Whitney test, comparing percentage of lesion remission test in each examination. Results: The percentage of lesion remission in quadruple-drug therapy was higher than in triple-drug therapy from the first visit until the first follow-up visit, with a p-value of 0.001. In addition, the mean percentage of lesion remission from first visit to last visit was 57.5% and the median was 70.9% in the quadruple therapy group, while in the triple-drug therapy group the mean was 52.5% and the median was 54.0% (p=0.720). Conclusion: We conclude that the quadruple-drug therapy has a more rapid resolution effect on chorioretinitis lesion compared to triple therapy. Keywords: toxoplasma chorioretinitis, quadruple-drug therapy, triple-drug therapyKartasasmita AMuntur WPEnus SIskandar EDove Medical Pressarticletoxoplasma chorioretinitisquadruple drug therapytriple-drug therapyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2133-2137 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	toxoplasma chorioretinitis quadruple drug therapy triple-drug therapy Ophthalmology RE1-994
spellingShingle	toxoplasma chorioretinitis quadruple drug therapy triple-drug therapy Ophthalmology RE1-994 Kartasasmita A Muntur WP Enus S Iskandar E Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
description	Arief Kartasasmita, Wendy P Muntur, Sutarya Enus, Erwin Iskandar Faculty of Medicine, Universitas Padjadjaran, Cicendo National Eye Hospital, Bandung, Indonesia Purpose: To compare the effectiveness of quadruple-drug therapy consisting of cotrimoxazole (trimethopin and sulfamethoxazole), clindamycin antibiotics, and oral corticosteroid versus triple therapy consisting of pyrimetamine, sulphadiazine, and oral corticosteroid in the resolution of toxoplasmic chorioretinitis. Methods: This was a double-blind randomized controlled trial with repeated measures using parallel design to compare the effectiveness of quadruple-drug therapy and triple-drug therapy in patients with toxoplasmic chorioretinitis. The measurement of lesion was done using automated computer software, calculating the average of lesion size from three fundus photographs taken from the baseline and at each follow-up visit. The analytical statistics were obtained using Mann–Whitney test, comparing percentage of lesion remission test in each examination. Results: The percentage of lesion remission in quadruple-drug therapy was higher than in triple-drug therapy from the first visit until the first follow-up visit, with a p-value of 0.001. In addition, the mean percentage of lesion remission from first visit to last visit was 57.5% and the median was 70.9% in the quadruple therapy group, while in the triple-drug therapy group the mean was 52.5% and the median was 54.0% (p=0.720). Conclusion: We conclude that the quadruple-drug therapy has a more rapid resolution effect on chorioretinitis lesion compared to triple therapy. Keywords: toxoplasma chorioretinitis, quadruple-drug therapy, triple-drug therapy
format	article
author	Kartasasmita A Muntur WP Enus S Iskandar E
author_facet	Kartasasmita A Muntur WP Enus S Iskandar E
author_sort	Kartasasmita A
title	Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
title_short	Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
title_full	Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
title_fullStr	Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
title_full_unstemmed	Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
title_sort	rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0e9fe9fe44e6402794f2b147b4524383
work_keys_str_mv	AT kartasasmitaa rapidresolutionoftoxoplasmachorioretinitistreatmentusingquadrupletherapy AT munturwp rapidresolutionoftoxoplasmachorioretinitistreatmentusingquadrupletherapy AT enuss rapidresolutionoftoxoplasmachorioretinitistreatmentusingquadrupletherapy AT iskandare rapidresolutionoftoxoplasmachorioretinitistreatmentusingquadrupletherapy
_version_	1718403846971064320

Rapid resolution of toxoplasma chorioretinitis treatment using quadruple therapy

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