The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis

Abstract We conducted a meta-analysis to analyse the effect of metformin on survival of pancreatic cancer patients at various stages. We performed a systematic search of PubMed, Embase, Cochrane, and Web of Science to identify all relevant studies. Summary hazard ratios (HR) of survival and 95% conf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaogang Li, Tong Li, Zhiqiang Liu, Shanmiao Gou, Chunyou Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ea18e3736f645db9a0837f238aec974
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0ea18e3736f645db9a0837f238aec974
record_format	dspace
spelling	oai:doaj.org-article:0ea18e3736f645db9a0837f238aec9742021-12-02T12:32:44ZThe effect of metformin on survival of patients with pancreatic cancer: a meta-analysis10.1038/s41598-017-06207-x2045-2322https://doaj.org/article/0ea18e3736f645db9a0837f238aec9742017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06207-xhttps://doaj.org/toc/2045-2322Abstract We conducted a meta-analysis to analyse the effect of metformin on survival of pancreatic cancer patients at various stages. We performed a systematic search of PubMed, Embase, Cochrane, and Web of Science to identify all relevant studies. Summary hazard ratios (HR) of survival and 95% confidence intervals (95% CI) were calculated with a fixed or random effects model according to inter-study heterogeneity. Nine retrospective cohort studies and two randomized controlled trials (RCTs) were eligible. There was a significant improvement in survival (HR = 0.86, 95% CI 0.76–0.97; P < 0.05) in the metformin group compared with control. Subgroup analysis indicated that metformin improved survival in patients with resection (HR = 0.79, 95% CI 0.69–0.91; P < 0.05) and patients with locally advanced tumors (HR = 0.68, 95% CI 0.55–0.84; P < 0.05) but not in patients with metastatic tumors, even when RCT data were included (HR = 0.99, 95% CI 0.70–1.40; P > 0.05), or were excluded (HR = 0.89, 95% CI 0.61–1.31; P > 0.05). This meta-analysis indicated that the effect of metformin does correlate with tumor stage but should be prudently considered given the limited and variable studies performed to data.Xiaogang LiTong LiZhiqiang LiuShanmiao GouChunyou WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaogang Li Tong Li Zhiqiang Liu Shanmiao Gou Chunyou Wang The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
description	Abstract We conducted a meta-analysis to analyse the effect of metformin on survival of pancreatic cancer patients at various stages. We performed a systematic search of PubMed, Embase, Cochrane, and Web of Science to identify all relevant studies. Summary hazard ratios (HR) of survival and 95% confidence intervals (95% CI) were calculated with a fixed or random effects model according to inter-study heterogeneity. Nine retrospective cohort studies and two randomized controlled trials (RCTs) were eligible. There was a significant improvement in survival (HR = 0.86, 95% CI 0.76–0.97; P < 0.05) in the metformin group compared with control. Subgroup analysis indicated that metformin improved survival in patients with resection (HR = 0.79, 95% CI 0.69–0.91; P < 0.05) and patients with locally advanced tumors (HR = 0.68, 95% CI 0.55–0.84; P < 0.05) but not in patients with metastatic tumors, even when RCT data were included (HR = 0.99, 95% CI 0.70–1.40; P > 0.05), or were excluded (HR = 0.89, 95% CI 0.61–1.31; P > 0.05). This meta-analysis indicated that the effect of metformin does correlate with tumor stage but should be prudently considered given the limited and variable studies performed to data.
format	article
author	Xiaogang Li Tong Li Zhiqiang Liu Shanmiao Gou Chunyou Wang
author_facet	Xiaogang Li Tong Li Zhiqiang Liu Shanmiao Gou Chunyou Wang
author_sort	Xiaogang Li
title	The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
title_short	The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
title_full	The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
title_fullStr	The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
title_full_unstemmed	The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
title_sort	effect of metformin on survival of patients with pancreatic cancer: a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0ea18e3736f645db9a0837f238aec974
work_keys_str_mv	AT xiaogangli theeffectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT tongli theeffectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT zhiqiangliu theeffectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT shanmiaogou theeffectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT chunyouwang theeffectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT xiaogangli effectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT tongli effectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT zhiqiangliu effectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT shanmiaogou effectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis AT chunyouwang effectofmetforminonsurvivalofpatientswithpancreaticcancerametaanalysis
_version_	1718393961134948352

The effect of metformin on survival of patients with pancreatic cancer: a meta-analysis

Ejemplares similares