Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.

It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those...

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Autores principales:	Markus Muehlhan, Ulrike Lueken, Jens Siegert, Hans-Ulrich Wittchen, Michael N Smolka, Clemens Kirschbaum
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ea192e1cbd14df49f7de9d699e4b236
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spelling	oai:doaj.org-article:0ea192e1cbd14df49f7de9d699e4b2362021-11-18T08:59:28ZEnhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.1932-620310.1371/journal.pone.0072576https://doaj.org/article/0ea192e1cbd14df49f7de9d699e4b2362013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23967320/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those stress reactions during the scanning procedure may influence task performance and neural correlates. However, the question how sympathetic arousal elicited by the scanning procedure itself may act as a potential confounder of fMRI data remains unresolved today. Thirty-seven scanner naive healthy subjects performed a simple cued target detection task. Levels of salivary alpha amylase (sAA), as a biomarker for sympathetic activity, were assessed in samples obtained at several time points during the lab visit. SAA increased two times, immediately prior to scanning and at the end of the scanning procedure. Neural activation related to motor preparation and timing as well as task performance was positively correlated with the first increase. Furthermore, the first sAA increase was associated with task induced deactivation (TID) in frontal and parietal regions. However, these effects were restricted to the first part of the experiment. Consequently, this bias of scanner related sympathetic activation should be considered in future fMRI investigations. It is of particular importance for pharmacological investigations studying adrenergic agents and the comparison of groups with different stress vulnerabilities like patients and controls or adolescents and adults.Markus MuehlhanUlrike LuekenJens SiegertHans-Ulrich WittchenMichael N SmolkaClemens KirschbaumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e72576 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markus Muehlhan Ulrike Lueken Jens Siegert Hans-Ulrich Wittchen Michael N Smolka Clemens Kirschbaum Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
description	It has been repeatedly shown that functional magnetic resonance imaging (fMRI) triggers distress and neuroendocrine response systems. Prior studies have revealed that sympathetic arousal increases, particularly at the beginning of the examination. Against this background it appears likely that those stress reactions during the scanning procedure may influence task performance and neural correlates. However, the question how sympathetic arousal elicited by the scanning procedure itself may act as a potential confounder of fMRI data remains unresolved today. Thirty-seven scanner naive healthy subjects performed a simple cued target detection task. Levels of salivary alpha amylase (sAA), as a biomarker for sympathetic activity, were assessed in samples obtained at several time points during the lab visit. SAA increased two times, immediately prior to scanning and at the end of the scanning procedure. Neural activation related to motor preparation and timing as well as task performance was positively correlated with the first increase. Furthermore, the first sAA increase was associated with task induced deactivation (TID) in frontal and parietal regions. However, these effects were restricted to the first part of the experiment. Consequently, this bias of scanner related sympathetic activation should be considered in future fMRI investigations. It is of particular importance for pharmacological investigations studying adrenergic agents and the comparison of groups with different stress vulnerabilities like patients and controls or adolescents and adults.
format	article
author	Markus Muehlhan Ulrike Lueken Jens Siegert Hans-Ulrich Wittchen Michael N Smolka Clemens Kirschbaum
author_facet	Markus Muehlhan Ulrike Lueken Jens Siegert Hans-Ulrich Wittchen Michael N Smolka Clemens Kirschbaum
author_sort	Markus Muehlhan
title	Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
title_short	Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
title_full	Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
title_fullStr	Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
title_full_unstemmed	Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.
title_sort	enhanced sympathetic arousal in response to fmri scanning correlates with task induced activations and deactivations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0ea192e1cbd14df49f7de9d699e4b236
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Enhanced sympathetic arousal in response to FMRI scanning correlates with task induced activations and deactivations.

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