FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis,...

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Autores principales:	Weiwei Liang, Xinjian Peng, Qingqing Li, Pingzhang Wang, Ping Lv, Quansheng Song, Shaoping She, Shiyang Huang, Keqiang Chen, Wanghua Gong, Wuxing Yuan, Vishal Thovarai, Teizo Yoshimura, Colm O’huigin, Giorgio Trinchieri, Jiaqiang Huang, Shuye Lin, Xiaohong Yao, Xiuwu Bian, Wei Kong, Jianzhong Xi, Ji Ming Wang, Ying Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ea1abe3c3234932b77c2016848d7dc0
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spelling	oai:doaj.org-article:0ea1abe3c3234932b77c2016848d7dc02021-12-02T14:40:52ZFAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis10.1038/s41467-020-19691-z2041-1723https://doaj.org/article/0ea1abe3c3234932b77c2016848d7dc02020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19691-zhttps://doaj.org/toc/2041-1723The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota.Weiwei LiangXinjian PengQingqing LiPingzhang WangPing LvQuansheng SongShaoping SheShiyang HuangKeqiang ChenWanghua GongWuxing YuanVishal ThovaraiTeizo YoshimuraColm O’huiginGiorgio TrinchieriJiaqiang HuangShuye LinXiaohong YaoXiuwu BianWei KongJianzhong XiJi Ming WangYing WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
description	The cytokine like protein FAM3D (Fam3D in mice) is highly expressed in the digestive tract with unknown role in colon pathophysiology. Here, by using gene deficient mice, the authors show that Fam3D is critically involved in colon homeostasis, host defense against colitis-associated carcinogenesis, and the balance of microbiota.
format	article
author	Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang
author_facet	Weiwei Liang Xinjian Peng Qingqing Li Pingzhang Wang Ping Lv Quansheng Song Shaoping She Shiyang Huang Keqiang Chen Wanghua Gong Wuxing Yuan Vishal Thovarai Teizo Yoshimura Colm O’huigin Giorgio Trinchieri Jiaqiang Huang Shuye Lin Xiaohong Yao Xiuwu Bian Wei Kong Jianzhong Xi Ji Ming Wang Ying Wang
author_sort	Weiwei Liang
title	FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
title_short	FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
title_full	FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
title_fullStr	FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
title_full_unstemmed	FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
title_sort	fam3d is essential for colon homeostasis and host defense against inflammation associated carcinogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0ea1abe3c3234932b77c2016848d7dc0
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_version_	1718390095115976704

FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

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