The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>

ABSTRACT Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P. falciparum HAD protein, phosphoglycolate phosphatase (PGP), regulates glycolysis and pe...

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Détails bibliographiques
Auteurs principaux: Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold
Format: article
Langue:EN
Publié: American Society for Microbiology 2019
Sujets:
CRISPR
Plasmodium falciparum
antimalarial
fosmidomycin
glycolysis
isoprenoid
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/0ea2ed8c7c8b4525becb3004db1c6787
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https://doaj.org/article/0ea2ed8c7c8b4525becb3004db1c6787

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