Changes in inflammatory response after endovascular treatment for type B aortic dissection.

This present study aims to investigate the changes in the inflammatory markers after elective endovascular treatment of Type B aortic dissection with aneurysm, as related to different anatomical features of the dissection flap in the paravisceral perfusion. Consecutive patients with type B aortic di...

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Autores principales:	Bernice L Y Cheuk, Y C Chan, Stephen W K Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0ea8c0a550dc4c049ca3164e2257bf70
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spelling	oai:doaj.org-article:0ea8c0a550dc4c049ca3164e2257bf702021-11-18T07:17:34ZChanges in inflammatory response after endovascular treatment for type B aortic dissection.1932-620310.1371/journal.pone.0037389https://doaj.org/article/0ea8c0a550dc4c049ca3164e2257bf702012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22655044/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This present study aims to investigate the changes in the inflammatory markers after elective endovascular treatment of Type B aortic dissection with aneurysm, as related to different anatomical features of the dissection flap in the paravisceral perfusion. Consecutive patients with type B aortic dissections with elective endovascular stent graft repair were recruited and categorized into different groups. Serial plasma levels of cytokines (Interleukin-1β, -6, -8, -10, TNF-α), chemokines (MCP-1), and serum creatinine were monitored at pre-, peri- and post-operative stages. The length of stent graft employed in each surgery was retrieved and correlated with the change of all studied biochemical parameters. A control group of aortic dissected patients with conventional medication management was recruited for comparing the baseline biochemical parameters. In total, 22 endovascular treated and 16 aortic dissected patients with surveillance were recruited. The endovascular treated patients had comparable baseline levels as the non-surgical patients. There was no immediate or thirty day-mortality, and none of the surgical patients developed post-operative mesenteric ischaemia or clinically significant renal impairment. All surgical patients had detectable pro-inflammatory mediators, but none of the them showed any statistical significant surge in the peri-operative period except IL-1β and IL-6. Similar results were obtained when categorized into different groups. IL-1β and IL-6 showed maximal levels within hours of the endovascular procedure (range, 3.93 to 27.3 higher than baseline; p = 0.001), but returned to baseline 1 day post-operatively. The change of IL-1β and IL-6 at the stent graft deployment was statistically greater in longer stent graft (p>0.05). No significant changes were observed in the serum creatinine levels. In conclusion, elective endovascular repair of type B aortic dissection associated with insignificant changes in inflammatory mediators and creatinine. All levels fell toward basal levels post-operatively suggesting that thoracic endovascular aortic repair is rather less aggressive with insignificant inflammatory modulation.Bernice L Y CheukY C ChanStephen W K ChengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37389 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernice L Y Cheuk Y C Chan Stephen W K Cheng Changes in inflammatory response after endovascular treatment for type B aortic dissection.
description	This present study aims to investigate the changes in the inflammatory markers after elective endovascular treatment of Type B aortic dissection with aneurysm, as related to different anatomical features of the dissection flap in the paravisceral perfusion. Consecutive patients with type B aortic dissections with elective endovascular stent graft repair were recruited and categorized into different groups. Serial plasma levels of cytokines (Interleukin-1β, -6, -8, -10, TNF-α), chemokines (MCP-1), and serum creatinine were monitored at pre-, peri- and post-operative stages. The length of stent graft employed in each surgery was retrieved and correlated with the change of all studied biochemical parameters. A control group of aortic dissected patients with conventional medication management was recruited for comparing the baseline biochemical parameters. In total, 22 endovascular treated and 16 aortic dissected patients with surveillance were recruited. The endovascular treated patients had comparable baseline levels as the non-surgical patients. There was no immediate or thirty day-mortality, and none of the surgical patients developed post-operative mesenteric ischaemia or clinically significant renal impairment. All surgical patients had detectable pro-inflammatory mediators, but none of the them showed any statistical significant surge in the peri-operative period except IL-1β and IL-6. Similar results were obtained when categorized into different groups. IL-1β and IL-6 showed maximal levels within hours of the endovascular procedure (range, 3.93 to 27.3 higher than baseline; p = 0.001), but returned to baseline 1 day post-operatively. The change of IL-1β and IL-6 at the stent graft deployment was statistically greater in longer stent graft (p>0.05). No significant changes were observed in the serum creatinine levels. In conclusion, elective endovascular repair of type B aortic dissection associated with insignificant changes in inflammatory mediators and creatinine. All levels fell toward basal levels post-operatively suggesting that thoracic endovascular aortic repair is rather less aggressive with insignificant inflammatory modulation.
format	article
author	Bernice L Y Cheuk Y C Chan Stephen W K Cheng
author_facet	Bernice L Y Cheuk Y C Chan Stephen W K Cheng
author_sort	Bernice L Y Cheuk
title	Changes in inflammatory response after endovascular treatment for type B aortic dissection.
title_short	Changes in inflammatory response after endovascular treatment for type B aortic dissection.
title_full	Changes in inflammatory response after endovascular treatment for type B aortic dissection.
title_fullStr	Changes in inflammatory response after endovascular treatment for type B aortic dissection.
title_full_unstemmed	Changes in inflammatory response after endovascular treatment for type B aortic dissection.
title_sort	changes in inflammatory response after endovascular treatment for type b aortic dissection.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0ea8c0a550dc4c049ca3164e2257bf70
work_keys_str_mv	AT bernicelycheuk changesininflammatoryresponseafterendovasculartreatmentfortypebaorticdissection AT ycchan changesininflammatoryresponseafterendovasculartreatmentfortypebaorticdissection AT stephenwkcheng changesininflammatoryresponseafterendovasculartreatmentfortypebaorticdissection
_version_	1718423643573190656

Changes in inflammatory response after endovascular treatment for type B aortic dissection.

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