BAP1/ASXL1 recruitment and activation for H2A deubiquitination

The tumor suppressor BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression. Here, the authors show how BAP1’s C-terminal extension auto-recruits it to nucleosomes, where the DEUBAD domain of ASXL1 increases BAP1’s affinity for ubiquitin to drive deub...

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Autores principales:	Danny D. Sahtoe, Willem J. van Dijk, Reggy Ekkebus, Huib Ovaa, Titia K. Sixma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0ea8dc04cd7544a2834c03123e450572
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spelling	oai:doaj.org-article:0ea8dc04cd7544a2834c03123e4505722021-12-02T17:32:51ZBAP1/ASXL1 recruitment and activation for H2A deubiquitination10.1038/ncomms102922041-1723https://doaj.org/article/0ea8dc04cd7544a2834c03123e4505722016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10292https://doaj.org/toc/2041-1723The tumor suppressor BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression. Here, the authors show how BAP1’s C-terminal extension auto-recruits it to nucleosomes, where the DEUBAD domain of ASXL1 increases BAP1’s affinity for ubiquitin to drive deubiquitination.Danny D. SahtoeWillem J. van DijkReggy EkkebusHuib OvaaTitia K. SixmaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Danny D. Sahtoe Willem J. van Dijk Reggy Ekkebus Huib Ovaa Titia K. Sixma BAP1/ASXL1 recruitment and activation for H2A deubiquitination
description	The tumor suppressor BAP1 is activated by ASXL1 to deubiquitinate mono-ubiquitinated H2A at K119 in Polycomb gene repression. Here, the authors show how BAP1’s C-terminal extension auto-recruits it to nucleosomes, where the DEUBAD domain of ASXL1 increases BAP1’s affinity for ubiquitin to drive deubiquitination.
format	article
author	Danny D. Sahtoe Willem J. van Dijk Reggy Ekkebus Huib Ovaa Titia K. Sixma
author_facet	Danny D. Sahtoe Willem J. van Dijk Reggy Ekkebus Huib Ovaa Titia K. Sixma
author_sort	Danny D. Sahtoe
title	BAP1/ASXL1 recruitment and activation for H2A deubiquitination
title_short	BAP1/ASXL1 recruitment and activation for H2A deubiquitination
title_full	BAP1/ASXL1 recruitment and activation for H2A deubiquitination
title_fullStr	BAP1/ASXL1 recruitment and activation for H2A deubiquitination
title_full_unstemmed	BAP1/ASXL1 recruitment and activation for H2A deubiquitination
title_sort	bap1/asxl1 recruitment and activation for h2a deubiquitination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0ea8dc04cd7544a2834c03123e450572
work_keys_str_mv	AT dannydsahtoe bap1asxl1recruitmentandactivationforh2adeubiquitination AT willemjvandijk bap1asxl1recruitmentandactivationforh2adeubiquitination AT reggyekkebus bap1asxl1recruitmentandactivationforh2adeubiquitination AT huibovaa bap1asxl1recruitmentandactivationforh2adeubiquitination AT titiaksixma bap1asxl1recruitmentandactivationforh2adeubiquitination
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BAP1/ASXL1 recruitment and activation for H2A deubiquitination

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