Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism

Abstract Speech is a complex and ambiguous acoustic signal that varies significantly within and across speakers. Despite the processing challenge that such variability poses, humans adapt to systematic variations in pronunciation rapidly. The goal of this study is to uncover the neurobiological base...

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Autores principales:	Esti Blanco-Elorrieta, Laura Gwilliams, Alec Marantz, Liina Pylkkänen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0eac020696c145d9a35e9ff6f53b891f
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spelling	oai:doaj.org-article:0eac020696c145d9a35e9ff6f53b891f2021-12-02T15:12:55ZAdaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism10.1038/s41598-020-79640-02045-2322https://doaj.org/article/0eac020696c145d9a35e9ff6f53b891f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79640-0https://doaj.org/toc/2045-2322Abstract Speech is a complex and ambiguous acoustic signal that varies significantly within and across speakers. Despite the processing challenge that such variability poses, humans adapt to systematic variations in pronunciation rapidly. The goal of this study is to uncover the neurobiological bases of the attunement process that enables such fluent comprehension. Twenty-four native English participants listened to words spoken by a “canonical” American speaker and two non-canonical speakers, and performed a word-picture matching task, while magnetoencephalography was recorded. Non-canonical speech was created by including systematic phonological substitutions within the word (e.g. [s] → [sh]). Activity in the auditory cortex (superior temporal gyrus) was greater in response to substituted phonemes, and, critically, this was not attenuated by exposure. By contrast, prefrontal regions showed an interaction between the presence of a substitution and the amount of exposure: activity decreased for canonical speech over time, whereas responses to non-canonical speech remained consistently elevated. Grainger causality analyses further revealed that prefrontal responses serve to modulate activity in auditory regions, suggesting the recruitment of top-down processing to decode non-canonical pronunciations. In sum, our results suggest that the behavioural deficit in processing mispronounced phonemes may be due to a disruption to the typical exchange of information between the prefrontal and auditory cortices as observed for canonical speech.Esti Blanco-ElorrietaLaura GwilliamsAlec MarantzLiina PylkkänenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esti Blanco-Elorrieta Laura Gwilliams Alec Marantz Liina Pylkkänen Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
description	Abstract Speech is a complex and ambiguous acoustic signal that varies significantly within and across speakers. Despite the processing challenge that such variability poses, humans adapt to systematic variations in pronunciation rapidly. The goal of this study is to uncover the neurobiological bases of the attunement process that enables such fluent comprehension. Twenty-four native English participants listened to words spoken by a “canonical” American speaker and two non-canonical speakers, and performed a word-picture matching task, while magnetoencephalography was recorded. Non-canonical speech was created by including systematic phonological substitutions within the word (e.g. [s] → [sh]). Activity in the auditory cortex (superior temporal gyrus) was greater in response to substituted phonemes, and, critically, this was not attenuated by exposure. By contrast, prefrontal regions showed an interaction between the presence of a substitution and the amount of exposure: activity decreased for canonical speech over time, whereas responses to non-canonical speech remained consistently elevated. Grainger causality analyses further revealed that prefrontal responses serve to modulate activity in auditory regions, suggesting the recruitment of top-down processing to decode non-canonical pronunciations. In sum, our results suggest that the behavioural deficit in processing mispronounced phonemes may be due to a disruption to the typical exchange of information between the prefrontal and auditory cortices as observed for canonical speech.
format	article
author	Esti Blanco-Elorrieta Laura Gwilliams Alec Marantz Liina Pylkkänen
author_facet	Esti Blanco-Elorrieta Laura Gwilliams Alec Marantz Liina Pylkkänen
author_sort	Esti Blanco-Elorrieta
title	Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
title_short	Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
title_full	Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
title_fullStr	Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
title_full_unstemmed	Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
title_sort	adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0eac020696c145d9a35e9ff6f53b891f
work_keys_str_mv	AT estiblancoelorrieta adaptationtomispronouncedspeechevidenceforaprefrontalcortexrepairmechanism AT lauragwilliams adaptationtomispronouncedspeechevidenceforaprefrontalcortexrepairmechanism AT alecmarantz adaptationtomispronouncedspeechevidenceforaprefrontalcortexrepairmechanism AT liinapylkkanen adaptationtomispronouncedspeechevidenceforaprefrontalcortexrepairmechanism
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Adaptation to mis-pronounced speech: evidence for a prefrontal-cortex repair mechanism

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